门冬氨酸阿奇霉素不同给药方式治疗小儿肺炎支原体感染的效果

Effect of azithromycin aspartate with different administration methods on Mycoplasma pneumoniae infection in children

目的比较门冬氨酸阿奇霉素不同给药方式治疗小儿肺炎支原体感染的效果。方法选取我院2018年8月至2019年8月收治的126例小儿肺炎支原体感染患儿为研究对象,按照随机数字表法将其分为观察组与对照组,每组63例。观察组给予门冬氨酸阿奇霉素序贯治疗,对照组给予门冬氨酸阿奇霉素持续静脉滴注。比较两组的治疗效果。结果两组患儿的体温恢复正常时间、咳嗽消失时间及肺部啰音消失时间比较,差异无统计学意义(P>0.05);观察组的住院费用低于对照组(P<0.05)。治疗后,两组FVC%、PEF%均较治疗前显著升高,IL-6、CRP水平均较治疗前显著降低(P<0.05),但组间比较,差异无统计学意义(P>0.05)。观察组的治疗总有效率高于对照组,胃肠道反应总发生率明显低于对照组(P<0.05)。治疗后,两组Na+水平均低于治疗前,但观察组高于对照组(P<0.05)。结论门冬氨酸阿奇霉素序贯治疗小儿肺炎支原体感染与持续静脉滴注的效果相当,但序贯治疗住院费用更低,胃肠道反应更轻,对Na+水平影响更小。

Objective To compare the effect of azithromycin aspartate with different administration methods on Mycoplasma pneumoniae infection in children.Methods One hundred and twenty-six children with Mycoplasma pneumoniae infection enrolled in our hospital from August 2018 to August 2019 were selected as the research objects and divided into observation group and control group according to random number table method,with 63 cases in each group.The observation group was given sequential treatment of azithromycin aspartate,while the control group was given continuous intravenous infusion of azithromycin aspartate.The therapeutic effects of the two groups were compared.Results There were no significant differences in the time of body temperature returning to normal and time of cough and pulmonary rales disappearance between the two groups(P>0.05);the hospitalization cost of the observation group was lower than that of the control group(P<0.05).After treatment,FVC%and PEF%in the two groups were significantly higher than those before treatment,while the levels of IL-6 and CRP were significantly lower than those before treatment(P<0.05),but there were no significant differences between the two groups(P>0.05).The total effective rate of treatment in the observation group was higher than that of the control group,and the total incidence of gastrointestinal reaction was significantly lower than that of the control group(P<0.05).After treatment,the Na+levels in the two groups were lower than those before treatment,but that of the observation group was higher than the control group(P<0.05).Conclusion The sequential and continuous intravenous infusion of azithromycin aspartate can obtain considerable effect in the treatment of Mycoplasma pneumoniae infection in children.However,sequential treatment has lower hospitalization cost,lighter gastrointestinal reaction and less influence on Na+level.