反义长链非编码RNA在肿瘤发生和发展中的研究进展

Progress in the studies on the role of antisense long chain noncoding RNA in tumor development

反义长链非编码RNA(long non coding RNA,lncRNA)是一类全新的RNA分子,在包括肿瘤的发生和发展在内的众多生命活动中发挥着重要作用。多种反义lncRNA在肿瘤患者组织中特异性表达,并且和患者的临床资料密切相关,是一种潜在的肿瘤分子标志物。Lnc RNA可以通过miRNA海绵和RBP结合等方式参与基因的调控,在肿瘤的细胞周期、凋亡、血管生成、侵袭与转移等过程中发挥重要功能。进一步研究反义lncRNA在肿瘤中的作用机制,对深入了解恶性肿瘤的病因发病学和RNA语言具有重要理论意义;同时,反义lncRNA作为分子标志或者潜在的靶点,在恶性肿瘤的早期诊断、疗效判断、预后预测,乃至基因治疗等方面也将具有广阔的临床应用前景。

Antisense long chain noncoding RNA(lncRNA)is a new class of RNA molecules.In recent years,antisense lncRNA has been found to play an important role in many life activities including tumorigenesis and development.It has become a hot topic in biological research in recent years.Because of the special structure,many antisense lncRNAs have specific expression in tumor tissues and are closely related to the clinical data of the patients.Thus,antisense lncRNA is a potential tumor molecular marker.Further functional studies have shown that lncRNA can participate in gene regulation by means of mi RNA sponge and RBP binding to play an important role in tumor cell cycle,apoptosis,angiogenesis,invasion and metastasis.More studies on the mechanisms of antisense lncRNA in cancer are of great theoretical significance in understanding the etiology and pathogenesis of malignant tumors and RNA language.At the same time,antisense lncRNA is a molecular marker or a potential target for the early diagnosis of malignant tumors.The antisense lncRNA may have a broad clinical application prospect in the evaluation of therapeutic effect,prognosis and even gene therapy.