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长链非编码RNA介导慢性难愈性创面愈合的机制研究进展 被引量:16

Research advances in healing mechanism of chronic refractory wounds mediated by long non-coding RNA
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摘要 慢性难愈性创面是指病因不明确、致伤因素多而复杂、愈合缓慢、治疗超过4周尚无明显愈合倾向的创面。慢性难愈性创面的形成及演变过程十分复杂,涉及创面组织再上皮化、细胞增殖、组织重塑及血管和淋巴管再生。长链非编码RNA表达异常可能参与了慢性难愈性创面的形成,但其具体的发病机制和相关分子生物学改变仍存有争议。本文针对慢性难愈性创面中长链非编码RNA调控角质形成细胞分化、成纤维细胞增殖、血管和淋巴管内皮细胞再生的过程及作用进行综述。 Chronic refractory wound refers to the wound with unclear etiology,multiple and complex injury factors,slow healing,and no obvious tendency of healing after treatment for 4 weeks.The formation and evolution process of chronic refractory wounds are very complex,involving re-epithelialization of wound tissue,cell proliferation,tissue remodeling,and angiogenesis and lymphangiogenesis.The abnormal expression of long non-coding RNA may be involved in the formation of chronic refractory wounds,but the specific pathogenesis and related molecular biological changes are still controversial.In this paper,we reviewed the process and role of long non-coding RNA in regulating keratinocyte differentiation,fibroblast proliferation,and regeneration of vascular and lymphatic endothelial cell in chronic refractory wounds.
作者 王鹏 尹斌 苏映军 贾赤宇 Wang Peng;Yin Bin;Su Yingjun;Jia Chiyu(School of Medicine,Xiamen University,Xiamen 361102,China;Department of Burns and Plastic&Wound Repair Surgery,Xiang′an Hospital of Xiamen University,Xiamen 361102,China)
出处 《中华烧伤杂志》 CAS CSCD 北大核心 2020年第8期758-761,共4页 Chinese Journal of Burns
基金 福建省自然科学基金(2019J01011)。
关键词 伤口愈合 长链非编码RNA 慢性难愈性创面 机制 Wound healing Long non-coding RNA Chronic refractory wounds Mechanism
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