泛素-蛋白酶体通路在增生性瘢痕中的作用研究进展

Research advances in the role of ubiquitin-proteasome pathway in hypertrophic scar

泛素-蛋白酶体通路是真核生物细胞内依赖ATP、非溶酶体途径的蛋白质降解通路,参与调控细胞周期、细胞凋亡、DNA修复、抗原呈递、受体内吞、细胞内信号转导等生物学过程。近期研究表明,泛素-蛋白酶体通路可通过干预转化生长因子β/Smad信号转导,成纤维细胞增殖、分化与凋亡等途经参与增生性瘢痕的发生和发展。本文就泛素-蛋白酶体通路中泛素连接酶、蛋白酶体、去泛素化酶在增生性瘢痕中的作用进行综述,以期为增生性瘢痕的防治提供新思路。

The ubiquitin-proteasome pathway is a protein degradation pathway that relies on ATP and non-lysosomal pathway in eukaryotic cells.It participates in the regulation of multiple biological processes,including cell cycle,apoptosis,DNA repair,antigen presentation,receptor endocytosis,intracellular signal transduction.Recent studies have found that the ubiquitin-proteasome pathway can participate in the formation and development of hypertrophic scar by regulating transforming growth factor beta/Smad signal transduction and proliferation,differentiation,and apoptosis of fibroblasts.This article summarizes the effects of ubiquitin ligase enzyme,proteasome,and deubiquitinating enzyme in ubiquitin-proteasome pathway in hypertrophic scar,in order to provide new idea for the prevention and treatment of hypertrophic scar.