血脂水平联合hs-CRP和Hcy检测在结缔组织病相关动脉粥样硬化性心血管疾病中的价值

The value of blood lipid level combined with hs CRP and Hcy detection in connective tissue disease related atherosclerotic cardiovascular disease

目的探讨血脂水平、超敏C反应蛋白(hs-CRP)和同型半胱氨酸(Hcy)在结缔组织病(CTD)相关动脉粥样硬化性心血管疾病(atherosclerotic cardiovascular disease,ASCVD)中的临床价值。方法选取2016年1月至2019年11月于本院风湿免疫科就诊的32例结缔组织病合并动脉粥样硬化性心血管疾病患者(实验组)及同期结缔组织病患者26例(对照组)。所有研究对象均检测血脂水平、hs-CRP和Hcy水平,分析其在预测ASCVD的中的临床价值。结果实验组血清TG、TC、LDL-C、hs-CRP和Hcy水平高于对照组,而HDL低于对照组,组间比较差异具有统计学意义(P<0.05);联合检测时准确率最高,明显高于各指标单独检测,差异具有统计学意义(P<0.05)。结论血清脂质水平、hs-CRP和Hcy是结缔组织病相关动脉粥样硬化性心血管疾病有效的预测指标,定期检测,可降低心血管事件的危险性,具有重要的临床价值。

Objective To investigate the clinical value of serum lipids,high-sensitivity C-reactive protein(hs-CRP)and homocysteine(Hcy)in atherosclerotic cardiovascular disease(ASCVD)associated with connective tissue disease(CTD).Methods From January 2016 to November 2019,32 patients with connective tissue disease and atherosclerotic cardiovascular disease(experimental group)and 26 patients with connective tissue disease(control group)in the same period.Blood lipid,hs CRP and Hcy levels were measured in all subjects,and their clinical value in predicting ASCVD was analyzed.Results The serum TG,TC,LDL-C,hs-CRP and Hcy levels in the experimental group were higher than the control group,while HDL level was lower than the control group,the difference between the two groups was statistically significant(P<0.05).The combined detection has the highest positive rate,which was significantly higher than the individual detection of each index,the difference was statistically significant(P<0.05).Conclusion Serum lipid level,hs CRP and Hcy are effective predictors of connective tissue disease related atherosclerotic cardiovascular disease.Regular detection can reduce the risk of cardiovascular events,which has important clinical value.