酒制女贞子生产工艺研究

Study on the Production Technology of Ligustrum lucidum

目的:以数控蒸煮锅为蒸制设备,优选酒制女贞子的最佳生产工艺条件。方法:采用高效液相色谱法测定女贞子中有效成分特女贞苷的含量,比较特女贞苷的含量和酒蒸后成品外观性状为评定指标,通过正交实验的方法优选酒制女贞子的最佳生产工艺条件。结果:特女贞苷的线性范围为0.2954~1.4770μg。回收率为98.2%,RSD=0.8105%。正交实验结果表明女贞子的最佳炮制工艺方案为黄酒拌后润1 h,110℃蒸制8 h,焖一夜,在80℃下干燥。结论:酒制女贞子生产工艺在生产中具有实用价值,符合GMP《药品生产管理规范》要求。

Objective The best conditions for the production of Ligustrum lucidum were selected by using CNC cooking pot as the steaming equipment.Methods High performance liquid chromatography(hplc)was used to determine the content of privet glycosides,compare the content of privet glycosides and the appearance of finished products after steaming as the evaluation index,and optimize the production process conditions of privet by orthogonal experiment.Results The linear range of the privet glycosides is 0.2954~1.4770μg,recovery was 98.2%,RSD=0.8105%.The results of orthogonal experiment showed that the best processing technology of Ligustrum lucidum was rice wine mixed with 1 h,110℃steamed for 8 h,overnight and dried at 80℃.Conclusion Alcohol production technology of Ligustrum lucidum has practical value in production and meets the requirements of GMP Good Manufacturing Practices for Pharmaceutical Products.