基于离子液体的双水相体系的分离机理及应用

Separation Mechanism and Application of Aqueous Biphasic Systems Based on Ionic Liquids

离子液体由于具有非挥发性、低毒、不易燃、热稳定性及化学稳定性高等优势,被认为是可替代传统有机溶剂的"绿色溶剂",在双水相体系构建方面得到了广泛应用。基于离子液体的双水相体系在生物大分子及有机化合物萃取分离方面具有独特优势,如萃取快速,操作简单,不需使用有害有机溶剂及复杂设备,易于规模化且生物兼容性好。该文综述了基于离子液体的双水相体系的两相分离机理及其在有机小分子及生物样品萃取纯化中的应用。并在此基础上讨论了离子液体双水相体系的优势、缺点以及未来发展趋势。

Ionic liquids were proposed as the potential replacement to the traditional organic solvents and widely used in the formation of aqueous biphasic systems,due to their unique properties,including non-volatility,low toxicity,non-flammability,high chemical and thermal stability.The aqueous biphasic systems based on ionic liquids offered their extensive benefits on the extraction of biomolecules and organic compounds,such as fast extraction,simple operation,easy scale and high biocompatibility without using the harmful organic solvents and complicated apparatus.In the paper,the phase separation mechanisms of aqueous biphasic systems and their applications in separation and purification of small organic molecules and biological samples were reviewed.The advantages,drawbacks and future development of the aqueous biphasic systems were also presented.