四项检验指标对病毒性肝炎和肝硬化的诊断价值

Diagnostic Value of Four Test Indices in Viral Hepatitis and Cirrhosis

选病毒性肝炎组样本42例、肝硬化组样本36例和健康对照组样本45例。用酶速率法和比色法测定上述样本中白蛋白(ALB)、总胆汁酸(TBA)、胆碱酯酶(ChE)和总胆红素(TBIL),对结果进行对比分析。三组样本ALB、TBA、ChE和TBIL浓度差异对比都有统计学意义(P<0.01)。病毒性肝炎组和健康对照组相比,ALB和ChE的浓度差异不大(P<0.01),而TBA和TBIL的浓度无差异(P>0.05)。病毒性肝炎组和对照组与肝硬化组相比,ALB和ChE的浓度均下降,而TBA和TBIL浓度则明显增大,两者有统计学差异(P<0.01)。肝硬化组的ALB、TBA、ChE和TBIL阳性率大于病毒性肝炎组,两者差异有显著统计学意义(P<0.01)。肝实质损伤程度与血清中ALB、TBA、ChE和TBIL的浓度紧密相关,联合检测这四项指标可作为诊断病毒性肝炎及肝硬化的重要依据。

A viral hepatitis group with 42 samples,a cirrhosis group with 36 samples and a healthy control group with 45 samples were selected.Albumin(ALB),total bile acid(TBA),cholinesterase(ChE)and total bilirubin(TBIL)were determined by enzyme rate method and colorimetric method.The results were compared and analyzed.There were significant differences in ALB,TBA,ChE and TBIL concentrations among the three group samples(P<0.01).Compared with the healthy control group,the concentrations of ALB and ChE had significant difference(P<0.01),but the concentrations of TBA and TBIL had no difference(P>0.05).Compared with the cirrhosis group,the concentrations of ALB and ChE in the viral hepatitis group and the control group decreased,while the concentration of TBA and TBIL increased significantly(P<0.01).The positive rates of ALB,TBA,ChE and TBIL in cirrhosis group were higher than those in the viral hepatitis group,the difference was significant(P<0.01).The degree of liver parenchymal injury was closely related to the concentrations of ALB,TBA,ChE and TBIL in serum.The combined detection of these four indicators can be used as an important basis for the diagnosis of viral hepatitis and cirrhosis.