桃红四物汤联合西医常规治疗缺血性脑卒中临床疗效Meta分析

A Meta-analysis of Clinical Effects of Taohong Siwu Decoction Combined with Conventional Western Medicine in the Treatment of Ischemic Stroke

目的:系统评价桃红四物汤联合西医常规治疗缺血性脑卒中的临床疗效。方法:计算机检索CNKI、VIP、Pub Med、EMBase等数据库,筛选从建库至2020年1月的桃红四物汤联合西医常规治疗缺血性卒中的随机对照试验(randomized controlled trial,RCT),并运用Rev Man 5.3软件对纳入研究进行Meta分析。结果:入选13篇文献,1274例患者。结果显示与西医常规组比较,联合组能显著提高临床有效率、改善神经功能缺损评分、降低血清炎性指标,差异具有统计学意义。结论:桃红四物汤联合西医常规治疗缺血性脑卒中优于单纯采用西医常规方法,但仍需更多大样本和设计严谨的RCT予以验证。

Objective For the sake of systematically evaluating the clinical efficacy of Taohong Siwu Decoction combined with conventional western medicine in the treatment of ischemic stroke.Methods The computer searched CNKI,VIP,Pub Med,EMbase and other databases,and screened a randomized controlled trial(RCT) of Taohong Siwu Decoction combined with conventional Western medicine for the treatment of ischemic stroke from the establishment of the database to January 2020,and used Rev Man5.3 software performs meta-analysis on the included studies.Results Thirteen literatures were included in 1274 patients.The consequences revealed that compared with the western medicine conventional group,the combined group could significantly improve clinical effectiveness,improve neurological deficit scores,and reduce serum inflammatory indexes.The differences are statistically significant.Conclusion Taohong Siwu Decoction combined with conventional western medicine for the treatment of ischemic stroke is more splendid than conventional western medicine alone.Nevertheless,more large samples and rigorous design of RCT are still needed for verification.