注射用牛肺表面活性剂与猪肺磷脂注射液治疗新生儿呼吸窘迫综合征的效果

Comparison of the efficacy of Curosurf and Calsurf in the treatment of neonatal respiratory distress syndrome

目的观察注射用牛肺表面活性剂(珂立苏)与猪肺磷脂注射液(固尔苏)治疗新生儿呼吸窘迫综合征效果。方法选取我院2017年8月至2019月8月收治106例新生儿呼吸窘迫综合征患儿,按随机数表法分为珂立苏组和固尔苏组,各53例,均给予气管插管呼吸支持。珂立苏组接受注射用牛肺表面活性剂气管滴注,固尔苏组接受猪肺磷脂注射液气管滴注。比较2组治疗前后血气指标、临床指标及并发症发生情况。结果治疗后2组血氧分压(PaO2)较治疗前显著增高(P<0.05),二氧化碳分压(PaCO2)较治疗前显著降低(P<0.05)。固尔苏组PaO2较珂立苏组显著增高(P<0.05),PaCO2较珂立苏组显著降低(P<0.05)。固尔苏组患儿用氧时间、机械通气时间及住院时间均短于珂立苏组,差异均具有统计学意义(均P<0.05)。2组动脉导管未闭、支气管肺发育不良、视网膜病、颅内出血、肺气漏、呼吸机相关肺炎发生率差异均无统计学意义(均P>0.05)。结论猪肺磷脂注射液与注射用牛肺表面活性剂治疗新生儿呼吸窘迫综合征均具有良好效果,猪肺磷脂注射液效果更优,但猪肺磷脂注射液价格昂贵,临床应根据患儿情况选择药物。

Objective To observe the effect of curosurf and calsurf on neonatal respiratory distress syndrome.Methods From August 2017 to August 2019,106 children with neonatal respiratory distress syndrome were selected and randomly divided into curosurf group and calsurf group,and 53 cases in each group.The curosurf group received a curosurf tracheal infusion,and the calsurf group received a calsurf tracheal infusion.The blood gas index,clinical index and complications of the two groups were compared before and after treatment.Results After treatment,PaO2 was significantly higher in the two groups than before treatment(P<0.05),and PaCO2 was significantly lower than that before treatment(P<0.05).PaO2 in curosurf group was significantly higher than that in calsurf group(P<0.05),and PaCO2 was significantly lower than that in calsurf group(P<0.05).The duration of oxygen,mechanical ventilation and hospital stay of children in the curosurf group were shorter than those in the calsurf group,and the differences were statistically significant(all P<0.05).There was no statistically significant difference in the incidence of arterial ducts,bronchopulmonary dysplasia,retinopathy,intracranial hemorrhage,pulmonary air leak,and ventilator-associated pneumonia in both groups(all P>0.05).Conclusion Both curosurf and calsurf have good effects on neonatal respiratory distress syndrome.Curosurf is more effective,but curosurf is expensive,and the drug should be selected according to the clinical situation of the child.