伏立康唑致视觉障碍的研究进展

Research progress of voriconazole-induced visual impairment

伏立康唑致视觉障碍常见,发生率约30%。本文从伏立康唑致视觉障碍的危险因素、发生机制、防范措施等方面综述了近年来国内外有关伏立康唑致视觉障碍的研究状况,指出药物体内浓度、基因多态性、高龄、肝功能状态、药物相互作用、给药方式是伏立康唑致视觉障碍的危险因素;发生机制可能是选择性诱导视网膜的视锥和视杆双极细胞而引起可逆性功能障碍;医护人员要密切关注伏立康唑致视觉障碍的危险因素,根据血药浓度优化给药方案,减少不良反应发生。

Visual impairment caused by voriconazole is common,with an incidence rate of about 30%.This article summarizes the research status of voriconazole-induced visual impairment in recent years in terms of risk factors,mechanism,and preventive measures of voriconazole-induced visual impairment.It is pointed out that the blood drug concentration,gene polymorphism,advanced age,liver function status,drug interaction,and administration methods are the risk factors for voriconazole-induced visual impairment;the mechanism may be the selective induction of cones of vision and rod bipolar cells of the retina and cause reversible dysfunction;medical staff should pay close attention to the risk factors of visual impairment caused by voriconazole,optimize the dosing regimen according to the blood drug concentration to reduce the occurrence of adverse reactions.