摘要
目的:分析用尼莫地平联合多奈哌齐治疗阿尔茨海默病的临床疗效。方法:将2019年1月至10月在开滦总医院接受治疗的80例阿尔茨海默病患者作为研究对象。将其随机分为尼莫地平组和尼-多组(40例/组)。为尼莫地平组患者使用尼莫地平进行治疗,为尼-多组患者使用尼莫地平联合多奈哌齐进行治疗。然后对比两组患者认知功能、日常生活活动能力的变化情况。结果:治疗前,两组患者的MMSE评分、ADL评分相比,P>0.05。治疗后,尼-多组患者的MMSE评分〔(19.37±2.13)分〕、ADL评分〔(82.35±4.17)分〕均高于尼莫地平组患者的MMSE评分〔(17.16±2.08)分〕、ADL评分〔(70.57±5.38)分〕,P<0.05。结论:对阿尔茨海默病患者采用尼莫地平联合多奈哌齐进行治疗可显著改善其认知功能,提高其日常生活活动能力。
Objective:To analyze the clinical efficacy of nimodipine combined with Donepezil in the treatment of Alzheimer’s disease.Methods:Eighty patients with Alzheimer’s disease who were treated at Kailuan General Hospital from January to October 2019 were enrolled in the study.They were randomly divided into nimodipine group and Nimodipine group(40 cases/group).Patients in the nimodipine group were treated with nimodipine,and patients in the Ni-multigroup were treated with nimodipine combined with Donepezil.Then the changes in cognitive function and daily life activities were compared between the two groups.Results:before treatment,MMSE score and ADL score of the two groups were compared,and P>0.05.After treatment,MMSE score(19.37±2.13)and ADL score(82.35±4.17)in the nimodipien group were higher than those in the Nimodipien group(17.16±2.08)and ADL score(70.57±5.38),P<0.05.Conclusion:Nimodipine combined with Donepezil can significantly improve the cognitive function and daily activity of Alzheimer’s disease patients.
作者
李超
狄丽丽
佟久芬
Li Chao;Di Lili;Tong Jiufen(Tangshan Kailuan General Hospital,Tangshan 063000,China;Kailuan Mental Health Center,Tangshan 063000,China)
