用右美托咪定对在ICU进行机械通气的患者实施麻醉镇静的效果观察

Effect of dexmedetomidine on anesthesia sedation in patients undergoing mechanical ventilation in ICU

目的:探讨使用右美托咪定对在重症监护室(ICU)进行机械通气的患者实施麻醉镇静的临床效果。方法:将2018年6月至2019年6月期间在南通瑞慈医院ICU进行机械通气的80例患者作为研究对象。将这80例患者分为A组和B组,每组各有40例患者。使用咪达唑仑注射液对A组患者进行麻醉镇静,使用盐酸右美托咪定注射液对B组患者进行麻醉镇静。然后,比较两组患者的各项临床指标。结果:在T1、T2、T3、T4,两组患者的Ramsay镇静评分相比,P>0.05。与A组患者相比,B组患者停药后被唤醒的时间、机械通气的时间均较短,其麻醉后谵妄、低血压的发生率均较低,P<0.05。两组患者麻醉后心动过缓的发生率相比,P>0.05。结论:使用右美托咪定对在ICU进行机械通气的患者实施麻醉镇静的效果显著,可有效地缩短其停药后被唤醒的时间,降低其不良反应的发生率。

Objective:To investigate the clinical effect of dexmedetomidine on anesthesia sedation in patients undergoing mechanical ventilation in intensive care unit(ICU).Methods:A total of 80 patients who underwent mechanical ventilation in ICU of Ruici Hospital in Nantong from June 2018 to June 2019 were selected as study subjects.The 80 patients were divided into group A and Group B,with 40 patients in each group.Midazolam injection was used for anesthesia sedation in group A,and dexmedetomidine hydrochloride injection was used for anesthesia sedation in group B.Then,the clinical indicators of the two groups were compared.Results:compared with Ramsay sedation scores at T1,T2,T3 and T4,P>0.05.Compared with group A,the time of awakening and mechanical ventilation after drug withdrawal was shorter in group B,and the incidence of post-anesthesia delirium and hypotension was lower in group B(P<0.05).The incidence of bradycardia after anesthesia was compared between the two groups(P>0.05).Conclusion:Dexmedetomidine has a significant effect on anesthesia sedation in patients undergoing mechanical ventilation in ICU,which can effectively shorten the time of being aroused after d rug withdrawal and reduce the incidence of adverse reactions.