早期肠内营养支持对重症急性胰腺炎患者预后及血清炎性细胞因子水平的影响

Effect of early enteral nutrition support on prognosis and serum inflammatory cytokines in patients with severe acute pancreatitis

目的:探讨并研究对重症急性胰腺炎(SAP)患者进行早期肠内营养支持对其预后及血清炎性细胞因子水平的影响。方法:将重庆市长寿区人民医院收治的102例SAP患者随机分为早期肠内营养支持组(EEN组,n=51)与常规营养支持组(RNS组,n=51)。对两组患者均进行对症治疗,在此基础上对EEN组患者与RNS组患者分别进行早期肠内营养支持与常规的营养支持,然后比较两组患者的各项指标。结果:治疗后,EEN组患者接受手术的比率、多器官功能障碍的发生率和死亡率均低于RNS组患者,其血清白细胞介素-6(IL-6)、白细胞介素-8(IL-8)和肿瘤坏死因子-α(TNF-α)的水平均低于RNS组患者,P<0.05。结论:对SAP患者进行对症治疗的基础上,对其实施早期肠内营养支持能有效地改善其血清炎性细胞因子的水平,降低其多器官功能障碍的发生率和死亡率。

Objective:To explore and study the effect of early enteral nutrition support on prognosis and serum inflammatory cytokine levels in patients with severe acute pancreatitis(SAP).Methods:a total of 102 SAP patients admitted to Chongqing Longevity District People’s Hospital were randomly divided into EEN group(N=51)and routine nutritional support group(RNS group,n=51).Symptomatic treatment was given to patients in both groups.On this basis,early enteral nutritional support and routine nutritional support were respectively given to patients in EEN group and RNS group.Then,various indicators of patients in the two groups were compared.Results:After treatment,the rate of surgery,incidence of multi-organ dysfunction,and mortality of EEN group were all lower than those of RNS group,and the levels of serum interleukin-6(IL-6),interleukin-8(IL-8),and tumor necrosis factor-α(TNF-α)were all lower than those of RNS group(P<0.05).Conclusion:On the basis of symptomatic treatment,early enteral nutrition support can effectively improve the level of serum inflammatory cytokines and reduce the incidence and mortality of multiorgan dysfunction in SAP patients.