脉冲振荡肺功能检测和呼出气一氧化氮检测在诊断咳嗽变异性哮喘中的应用价值

The value of pulsed oscillatory lung function test and exhaled nitric oxi de test in the diagnosis of cough variant asthma

目的:观察脉冲振荡肺功能检测和呼出气一氧化氮(FeNO)检测在诊断咳嗽变异性哮喘中的应用价值。方法:将2018年4月至2019年4月在合肥市第二人民医院就诊的94例慢性咳嗽患者作为研究对象。将其中44例咳嗽变异性哮喘(CVA)患者作为CVA组,将其中50例非CVA患者作为非CVA组。对两组患者均进行常规的肺功能检测、支气管舒张试验、脉冲振荡肺功能检测和FeNO检测。然后比较两组患者的FEV1%、脉冲振荡肺功能指标(包括Z5%、R5%和X5%)和FeNO的水平。结果:1)CVA组患者接受支气管舒张试验后其FEV1%较接受支气管舒张试验前明显提高,其Z5%、R5%、X5%均较接受支气管舒张试验前明显下降,P<0.05。非CVA组患者接受支气管舒张试验前后其FEV1%、Z5%、R5%、X5%相比,P>0.05。2)进行相关性分析的结果显示,CVA组患者接受支气管舒张试验前后其FEV1%与Z5%、R5%、X5%均呈负相关,P<0.05。3)与非CVA组患者比较,CVA组患者FeNO的水平较高,P<0.05。结论:脉冲振荡肺功能检测和FeNO检测在诊断CVA中的应用价值较高。

Objective:To observe the value of pulsed oscillatory lung function detection and exhaled nitric oxide(FeNO)detection in the diagnosis of cough variant asthma.Methods:94 patients with chronic cough admitted to Hefei Second People’s Hospital from April 2018 to April 2019 were studied.Forty-four patients with cough variant asthma(CVA)were treated as CVA group,and 50 patients with non-CVA were treated as non-CVA group.Routine lung function test,bronchodilation test,pulsed oscillatory lung function test and FeNO test were performed in both groups.FEV1%,pulsed oscillatory lung function indicators(including Z5%,R5%and X5%),and FeNO levels were then compared between the two groups.Results:1)FEV1%of patients in the CVA group were significantly higher than those before bronchial diastolic test,and the fEV1%of patients in the CVA group were significantly lower than those before bronchial diastolic test(Z5%,R5%,x5%),P<0.05.Compared with FEV1%,Z5%,R5%and X5%in non-cva group,P>0.05.2)Correlation analysis showed that FEV1%of patients in the CVA group were negatively correlated with Z5%,R5%and X5%before and after bronchial diastolic test(P<0.05).3)Compared with the non-CVA group,the level of FeNO in the CVA group was higher(P<0.05).Conclusion:Pulsed oscillatory lung function detection and FeNO detection are of high value in the diagnosis of CVA.