减重代谢手术在肥胖合并2型糖尿病中的研究进展

Research progress of bariatric and metabolic surgery in obesity combined with type 2 diabetes

减重代谢手术是近几年来出现的一个新概念,通过外科手段来降低肥胖病人体重,改善2型糖尿病病人血糖以降低其并发症对人体带来的危害,自减重外科概念提出以来,对相关代谢研究产生了极大的影响。减重代谢手术通过缓解胰岛素抵抗,改善胰岛素受体敏感性等控制或治愈2型糖尿病及其所引起的微血管病变、高血脂、多囊卵巢综合征、癌症等并发症。此文通过综述国内外相关文献,对减重代谢手术的历史现状、安全性、有效性及相关机制进行总结讨论,以促进临床对减重外科的认识及推动减重外科在临床中应用。

Bariatric-metabolic surgery,a new concept emerging in recent years,is a discipline that reduces the body weight of obese patients and improves the blood glucose of typeⅡdiabetics to reduce the harm of its complications by surgery.Since bariatric-metabolic surgery was put forward,it has been exerting a great impact on the metabolic research.Bariatric-metabolic surgery could control or cure type 2 diabetes and its complications,such as microvascular disease,hyperlipidemia,polycystic ovary syndrome,cancer,by alleviating insulin resistance and improving insulin receptor sensitivity.This paper summarized the historical status,safety,effectiveness and mechanisms of bariatric-metabolic surgery by reviewing the pertinent literature at home and abroad to promote clinical understanding and application of bariatric-metabolic surgery in clinical practice.