不同血清尿酸水平与心血管疾病危险因素的相关性研究

Association of different serum uric acid and the risk factors of cardiovascular disease

目的研究血清尿酸(serum uric acid,SUA)水平与心血管疾病(cardiovascular disease,CVD)危险因素的相关性。方法采用整体抽样的方法,对2017年7月至10月桂林医学院附属医院体检部成年健康体检者,共10286例(男性5983例,女性4303例)资料完整的体检人群纳入统计,分析血清尿酸水平与心血管疾病危险因素的相关性。结果⑴高尿酸血症(hyperuricemia,HUA)患者共2867例(HUA组),SUA正常者7419例(对照组),HUA组年龄、收缩压、舒张压、尿素氮、肌酐、空腹血糖、体重指数、谷草转氨酶、谷丙转氨酶、甘油三酯、总胆固醇、低密度脂蛋白胆固醇均高于对照组,高密度脂蛋白胆固醇低于对照组(P<0.01),男女心血管疾病危险因素均随着SUA水平的增高而逐渐异常(P<0.05)。⑵统计人群中,随着SUA水平的升高,男性SUA第四分位(Q4)组高血压、脂代谢异常、超重或肥胖的患病率分别为26.35%、57.17%及76.65%,男性高空腹血糖患病率呈“U”型分布;女性Q4组高空腹血糖症、高血压、脂代谢异常、超重或肥胖的患病率分别为11.43%、23.70%、32.25%及52.70%。⑶校正各影响因素后,Logistic回归分析显示,与SUA第一分位(Q1)组相比,男性Q4组高血压、脂代谢异常、超重或肥胖的患病风险分别增高68.2%、156%、246%,高空腹血糖风险降低49%;女性Q4组高空腹血糖、高血压、脂代谢异常、超重或肥胖的患病风险分别增高51.8%、38.5%、186%和192%。结论血清尿酸水平的升高反映了心血管疾病危险因素的患病风险增加。

Objective To study the association between serum uric acid(SUA)level and risk factors of cardiovascular disease(CVD).Methods A survey of health examination population from the physical examination department of Affiliated Hospital of Guilin Medical College from July to October 2017 was performed by using cluster sampling.And 10286 subjects(5983 males and 4303 females)were collected and analysied the association between level of serum uric acid and the risks of cardiovascular disease.Results⑴There were 2867 patients with hyperuricemia(HUA group)and 7419 patients with normal SUA(control group).The age,systolic blood pressure,diastolic blood pressure,urea nitrogen,creatinine,fasting blood glucose,body mass index,aspartate aminotransferase,alanine aminotransferase,triglyceride,total cholesterol,low-density lipoprotein cholesterol of the HUA group were all higher than those of the control group,while the high-density lipoprotein cholesterol was lower than that of the control group(P<0.01),the risk factors of cardiovascular disease in both men and women were gradually abnormal with the increase of SUA level(P<0.05).⑵In the statistical subjects,with the increase of SUA level,the prevalence of hypertension,dyslipidemia,overweight or obesity in the fourth SUA quartile(Q4)of men were 26.35%,57.17%and 76.65%respectively,and the prevalence of high fasting plasma glucose in men presented a U-shaped distribution;In Q4 group of women,the prevalence of high fasting plasma glucose,hypertension,dyslipidemia,overweight or obesity were 11.43%,23.70%,32.25%and 52.70%respectively.⑶After adjusting for various influencing factors,Logistic regression analysis showed that compared with the first SUA quartile(Q1),the risks of hypertension,dyslipidemia and overweight or obesity in the Q4 group of men were increased by 68.2%,156%and 246%respectively,and the risk of high fasting plasma glucose was decreased by 49%,while the risks of high fasting plasma glucose,hypertension,dyslipidemia and overweight or obesity in Q4 group of women were increased by 51.8%,38.5%,186%and 192%respectively.Conclusion Elevated SUA level is significantly associated with increased risk factors of the cardiovascular disease.