细胞因子在药物性肝损伤中的研究现状及应用价值

Current research status and application value of cytokines in drug-induced liver injury

药物性肝损伤(DILI)是指使用一种或多种药物后,由药物或其他代谢产物引起的肝脏损害。因药物种类繁多、不同个体之间差异较大等原因,DILI临床诊断存在诸多困难,寻找新的生物标志物成为学者们的研究热点。细胞因子在DILI尤其是特异质型DILI中具有关键作用。概述了不同细胞因子在DILI中的作用及其可预测DILI严重程度、评估预后等应用价值,认为细胞因子作为DILI生物标志物具有广阔的应用前景。

Drug-induced liver injury(DILI)refers to liver injury caused by one or more drugs or their metabolites after use.Due to the various types of drugs and large differences between individuals,there are many difficulties in the clinical diagnosis of DILI,and the search for new biomarkers has become a research hotspot.Related studies have shown that cytokines play a key role in DILI,especially idiosyncratic DILI.This article outlines the role of different cytokines in DILI and their value in predicting the severity and evaluating prognosis of DILI.It is pointed out that cytokines have a broad application prospect as biomarkers for DILI.