瓜环与药物地丹诺辛的络合作用研究

Study of the host-guest interaction between cucurbit[n]urils and didanosine

选取了三种具有不同空腔大小的瓜环:对称四甲基六元瓜环(TMeQ[6])、七元瓜环(Q[7])、八元瓜环(Q[8]),并应用核磁共振技术、热重分析技术、红外光谱等分析手段探究了这三种瓜环与药物分子地丹诺辛(DDI)的相互作用。实验结果表明:这三种具有不同空腔大小的瓜环与DDI之间具有不同的作用模式。DDI与Q[7]、Q[8]发生了主客体作用,地丹诺辛的呋喃环基团进入了瓜环的空腔。而且形成包结配合物后,DDI的热稳定性得到显著提高。而DDI与TMeQ[6]并没有发生作用。

Three kinds of cucurbit[n]urils including TMeQ[6],Q[7]and Q[8]were employed as hosts,the supramolecular self-assembly between these cucurbit[n]urils with didanosin(DDI)guest had been studied by 1HNMR spectroscopy,TGA Thermogravimetric analysis and FTIR spectroscopy.The results showed that there were different modes of interaction between these different cucurbit[n]uril and DDI.for the Q[7]-DDI system,the furan ring and partial alkyl chain of the guest molecule reside within the cavity of the Q[7]and Q[8]host,and the thermal stability of DDI was also significantly improved after forming the inclusion complex.While there was not interaction between TMeQ[6]and DDI.