急性淋巴细胞白血病患者miR-429表达分析

The expression of miR-429 in acute lymphoblastic leukemia patients

目的探讨急性淋巴细胞白血病患者miR-429表达情况。方法选取30例急性淋巴细胞白血病患者作为观察组,另选同期30例健康体检者作为对照组。比较两组研究对象miR-429表达水平;比较观察组miR-429不同表达水平患者年龄、性别、白细胞计数、血红蛋白、乳酸脱氢酶、骨髓原始细胞比例、危险分级、生存时间。结果观察组miR-429表达水平(2.48±0.15)高于对照组的(0.92±0.06),差异有统计学意义(P<0.05)。观察组30例患者中miR-429低表达16例,高表达14例。miR-429高表达患者年龄、性别、血红蛋白水平与miR-429低表达患者比较差异无统计学意义(P>0.05);miR-429高表达患者白细胞计数、乳酸脱氢酶、骨髓原始细胞比例、危险分级均高于miR-429低表达患者,生存时间短于miR-429低表达患者,差异有统计学意义(P<0.05)。结论miR-429表达和急性淋巴细胞白血病患者的预后有密切关系,可以作为评价预后的参考指标。

Objective To discuss the expression of miR-429 in acute lymphoblastic leukemia patients.Methods There were 30 acute lymphoblastic leukemia patients selected as the observation group,and concurrent 30 healthy examinees as the control group.The expression of miR-429 of the two groups was compared.The age,gender,white blood cell count,hemoglobin,lactate dehydrogenase,bone marrow primordial cells ratio,risk classification,and survival time of patients with different expression levels of miR-429 in the observation group were compared.Results The expression of miR-429(2.48±0.15)of the observation group was higher than that of the control group(0.92±0.06),and the difference was statistically significant(P<0.05).Among the 30 patients in the observation group,16 cases had low expression of miR-429 and 14 cases had high expression of miR-429.There was no statistically significant difference in age,gender,hemoglobin of miR-429 high expression patients compared with miR-429 low expression patients(P>0.05).White blood cell count,lactate dehydrogenase,bone marrow primordial cells ratio and risk classification of patients with high expression of miR-429 were higher than those of patients with low expression of miR-429,and survival time was shorter than that of patients with high expression of miR-429,and the difference was statistically significant(P<0.05).Conclusion The expression of mir-429 is closely related to the prognosis of patients with acute lymphoblastic leukemia,which can be used as a reference index to evaluate the prognosis.