52例血液病患者合并带状疱疹的临床分析

Clinical analysis of herpes zoster in 52 patients with hematopathy

目的分析52例血液病患者合并带状疱疹的临床症状及其危险因素。方法选取52例血液病合并带状疱疹患者作为研究组,另选同期52例血液病无并发症患者作为对照组。对两组患者的临床资料进行回顾性分析,经单因素分析筛选可能存在带状疱疹的危险因素。结果两组患者性别、住院时间比较,差异无统计学意义(P>0.05);研究组患者年龄≥60岁、化疗、糖尿病、粒细胞缺乏症及疾病未缓解占比分别为65.38%、75.00%、65.38%、78.85%、73.08%,均高于对照组的44.23%、44.23%、32.69%、30.77%、19.23%,差异有统计学意义(P<0.05)。血液病合并带状疱疹患者发疹前有轻度乏力、纳差及呕吐等全身症状,其中25例患者有发热症状,部分化疗患者有骨髓抑制情况。皮损类型中普通型41例,严重型6例,顿挫型5例,同时患者患处皮肤出现灼热感或神经痛。带状疱疹疾病多发生于多发性骨髓瘤及淋巴瘤中。结论对于血液病合并带状疱疹的危险因素,应及时采取有效治疗措施,降低血液病合并带状疱疹的发生率。

Objective To analyze the clinical symptoms and risk factors of herpes zoster in patients with hematopathy.Methods There were 52 herpes zoster patients with hematopathy selected as the research group,and another 52 herpes zoster patients without hematopathy as the control group.The clinical data of the two groups was retrospectively analyzed,and the risk factors for herpes zoster were screened by single factor analysis.Results There was no statistically significant difference in gender and hospitalization time between the two groups(P>0.05).The proportion of patients in the research group who were≥60 years old,chemotherapy,diabetes,agranulocytosis,and unrelieved disease were 65.38%,75.00%,65.38%,78.85%,73.08%,which were higher than those of the control group 44.23%,44.23%,32.69%,30.77%,19.23%,and the difference was statistically significant(P<0.05).Before the eruption,the patients with hematopathy and herpes zoster had some systemic symptoms,such as mild asthenia,poor appetite and vomiting.Among them,25 patients had fever symptoms,and some chemotherapy patients had myelosuppression.There were 41 cases of common type of skin lesion,6 cases of severe type,and 5 cases of frustration type.At the same time,the patient’s skin appeared burning or neuralgia.Herpes zoster disease usually occurred in multiple myeloma and lymphoma.Conclusion For the risk factors of herpes zoster and hematopathy,effective treatment measures should be taken in time to reduce the incidence of hematopathy combined with herpes zoster.