游离核酸甲基化检测在肿瘤精准诊疗中的应用

The application of free nucleic acid methylation in accurate diagnosis and treatment of tumor

核酸甲基化是基因表观遗传学修饰的一种重要方式,也是肿瘤最常见的驱动性分子事件。检测核酸甲基化游离形式不但能够对肿瘤进行早期辅助诊断及预后判断,而且可避免传统肿瘤组织活检方法侵入性和肿瘤异质性等问题。本文将回溯游离核酸甲基化检测在肿瘤诊断中的应用现状,剖析游离核酸甲基化检测面临的挑战,并对其临床应用前景进行展望。

It is one of the most important forms of nucleic acid methylation in gene epigenetic modification and the most common driving molecular event in tumors.Detection of the free form nucleic acid can not only assist in early diagnosis and prognosis of tumors,but also avoid the problems of invasion and tumor heterogeneity caused by traditional tumor biopsy methods.In the present paper,the application status of free nucleic acid methylation detection in tumor diagnosis was reviewed,the challenges faced by free nucleic acid methylation detection were analyzed,and prospect of its clinical application was prospected.