ACI患者血清PTX3 hs-CRP及APN水平与颈动脉粥样硬化斑块稳定性的相关性

Relationship between serum PTX3,hs-CRP and APN levels and carotid atherosclerotic plaque stability in ACI patients

目的探讨急性脑梗死患者血清五聚素3、超敏C反应蛋白、脂联素水平与颈动脉粥样硬化斑块稳定性的关系.方法将134例急性脑梗死患者设为ACI组,60名健康志愿者设为对照组.比较两组血清五聚素3、超敏C反应蛋白及脂联素水平,根据颈动脉彩色多普勒超声检查结果 将ACI组患者进行分层分析,采用多因素Logistic回归分析探讨血清五聚素3、超敏C反应蛋白及脂联素水平与患者颈动脉斑块稳定性的关系.结果 ACI组血清五聚素3、超敏C反应蛋白水平显著高于对照组(P<0.01),脂联素水平显著低于对照组(P<0.01).不稳定斑块急性脑梗死患者血清五聚素3水平显著高于稳定斑块患者及无斑块患者(P<0.01),脂联素水平显著低于稳定斑块患者及无斑块患者(P<0.01).血清五聚素3及脂联素水平是影响急性脑梗死患者颈动脉粥样硬化斑块稳定性的独立危险因素(P<0.01).结论急性脑梗死患者血清五聚素3、超敏C反应蛋白水平较高、脂联素水平较低,血清五聚素3及脂联素水平是影响急性脑梗死颈动脉斑块稳定性的独立危险因素.

Objective To investigate the relationship between serum PTX3,hs-CRP and APN levels and carotid atherosclerotic plaque stability in ACI patients.Methods 134 patients with acute cerebral infarction were set as ACI group,and 60 healthy volunteers as control group.The serum PTX3,hs-CRP and APN levels of the two groups were compared,and the patients in the ACI group were stratified according to the results of carotid color Doppler ultrasound.Multivariate logistic regression analysis was used to explore the relationship between serum PTX3,hs-CRP,APN levels and carotid plaque stability.Results Serum PTX3 and hs-CRP levels in ACI group were significantly higher than those in control group(P<0.01),APN levels in ACI group were significantly lower than those in control group(P<0.01),PTX3 levels in ACI patients with unstable plaques were significantly higher than those with stable plaques and non-plaque groups(P<0.01),and APN levels in unstable plaques were significantly lower than those with stable plaques and non-plaque groups(P<0.01).Serum PTX3 and APN levels were independent risk factors that affect the stability of carotid atherosclerotic plaques in patients with acute cerebral infarction(P<0.01).Conclusions Serum PTX3 and hs-CRP levels in ACI patients are higher than those in healthy people,and APN levels are lower than those in healthy people.Serum PTX3 and APN levels are independent risk factors that affect the stability of carotid plaque in acute cerebral infarction.