布地奈德气雾剂联合白三烯受体拮抗剂治疗儿童喘息性支气管炎临床研究

Clinical study of budesonide aerosol combined with leukotriene receptor antagonist in the treatment of children with asthmatic bronchitis

目的探讨布地奈德气雾剂联合白三烯受体拮抗剂治疗儿童喘息性支气管炎临床疗效.方法将108例喘息性支气管炎患儿按照用药方案分为观察组与对照组,每组54例.两组均在对症支持治疗的基础上给予布地奈德气雾剂治疗,观察组联合白三烯受体拮抗剂治疗,观察1周.比较两组喘息、咳嗽、哮鸣音及湿啰音消失时间.比较治疗前后两组最大呼气峰流速、用力肺活量、第1秒用力呼气容积及血清白细胞介素-10、白细胞介素-12水平.比较两组治疗期间不良反应发生率.结果 观察组喘息、咳嗽、哮鸣音及湿啰音消失时间显著早于对照组(P<0.01).治疗后两组大呼气峰流速、用力肺活量、第1秒用力呼气容积水平均显著高于治疗前(P<0.01),观察组较对照组升高更显著(P<0.01).治疗后两组白细胞介素-10水平均较治疗前显著降低(P<0.01),白细胞介素-12水平均较治疗前显著升高(P<0.01),观察组较对照组变化更显著(P<0.01).两组不良反应发生率比较差异无统计学意义(P>0.05).结论布地奈德气雾剂联合白三烯受体拮抗剂治疗喘息性支气管炎患儿效果显著,有利于缓解临床症状,改善肺功能,调节血清白细胞介素-10、白细胞介素-12水平,安全性高.

Objective To investigate the application value of budesonide aerosol combined with leukotriene receptor antagonist in the treatment of children with asthmatic bronchitis.Methods 108 children with asthmatic bronchitis were divided into observation group and control group according to the drug regimen,with 54 cases in each group.On the basis of symptomatic supportive treatment,the control group was treated with budesonide aerosol,and the observation group was treated with budesonide aerosol+leukot­riene receptor antagonist for 1 week.The disappearance time of wheezing,coughing,wheezing and wet rales were compared between the two groups.The levels of PEF,FVC,FEVl and serum interleukin-10 and interleukin-12 in the two groups were compared before and after treatment.Compare the incidence of adverse reactions during treatment between the two groups.Results The disappearance time of wheezing,coughing,wheezing and wet rales in the observation group was significantly shorter than that in the con­trol group(P<0.01).After treatment,the levels of PEF,FVC,and FEVl in the two groups were sig­nificantly higher than before treatment(P<0.01),and the observation group increased more significantly than the control group(P<0.01).After treatment,the levels of interleukin-10 were significantly lower than before treatment(P<0.01),and the levels of interleukin-12 were significantly higher than before treatment(P<0.01).The observation group changed more significantly than the control group(P<0.01).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions Budesonide aero-sol combined with leukotriene receptor antagonist is effective in treating children with asthmatic bronchitis,which is beneficial to relieve clinical symptoms,improve lung function,and adjust serum interleukin-10 and interleukin-12 levels,with high security.