间充质干细胞治疗男性不育的研究进展

Mesenchymal stem cells for the treatment of male infertility

间充质干细胞(MSC)是一类具有自我更新、多向分化能力和低免疫原性的多功能细胞,近年来已被广泛应用于生命科学和医学领域。男性不育的病因复杂,目前尚未有理想的治疗手段。MSC的多向分化潜能及旁分泌特性为男性不育患者的康复带来了新的希望。MSC根据其来源不同,可分为骨髓MSC、脂肪MSC和脐带MSC等。这些类型的MSC已经开展了大量的体内外研究,并取得了令人满意的结果。众多研究表明MSC在特殊条件诱导下或移植入睾丸后,能够分化为生殖细胞。同时,MSC体内移植后能分泌营养因子,改善局部生精微环境并重塑精子发生过程。本文将对MSC在男性不育领域的研究进展和应用前景作一综述。

Mesenchymal stem cells(MSC),as a type of multifunction cells capable of self-renewal and multi-directional differentiation and with a low immunogenicity,have been widely applied in life sciences and medicine in recent years.Male infertility is very complicated pathogenically and there is no ideal method for its treatment.The potential ability of multi-differentiation and paracrine function of MSCs is bringing new hope to patients with male infertility.MSCs can be derived from the bone marrow,adipose tissue,and umbilical cord,on which lots of studies,either in vitro or in vivo,have been conducted and achieved satisfactory results.Many findings indicate that MSCs can differentiate into germ-like cells if specifically induced or transplanted into the testis,improve the local microenvironment of spermatogenesis and reconstruct the spermatogenic process by secreting nutritional factors after transplantation.This article presents an overview of the advances in the studies and application prospects of MSCs in male infertility.