黄连温胆汤治疗代谢综合征研究进展

Effect of Huanglian Wendantang in Treatment of Metabolic Syndrome

代谢综合征(MS)是以中心性肥胖、胰岛素抵抗、高血压和高脂血症为特征的病理状态。随着现代社会不良饮食习惯、生活方式的增加,尤其是久坐少动的不良生活习惯,均导致MS的患病率逐年上升。据相关资料预计,2040年全球MS患者人数将达到25.68亿左右,严重危害人类生命健康。黄连温胆汤作为清热燥湿、理气化痰、和胃利胆的中医名方,已被现代药理学证实具有显著的降脂、降糖、抗炎等药理作用,被广泛用于代谢性疾病、心血管系统疾病等多个系统疾病的治疗。近年来大量研究证明黄连温胆汤治疗MS具有明显疗效,在临床疗效方面,能明显改善MS患者肥胖、血脂紊乱、糖代谢异常及高血压病理状态,同时还可干预机体中的炎症状态、前血栓状态及血管调节异常等潜在危险因素,具有安全性高,副作用少的特点;实验研究方面,能通过干预胰岛素信号转导、减轻炎症反应、抗氧化应激等途径,增强胰岛素的敏感性,改善MS动物模型及细胞模型的胰岛素抵抗程度。笔者通过检索PubMed,中国知网,维普,万方等数据库,从理论基础研究、临床疗效研究和实验机制研究3个方面,将近年来黄连温胆汤治疗MS的报道研究做一详细综述,以期为以后深入阐明黄连温胆汤治疗MS的作用机制和该方的开发及临床推广提供一定的科学参考。

Metabolic syndrome(MS)is a pathological condition characterized by central obesity,insulin resistance,hypertension,and hyperlipidemia.With the increase of poor dietary habits and lifestyles in modern society,especially the poor living habits of sedentariness and less movement,the prevalence of MS has increased year by year.According to relevant data,the number of MS patients worldwide will reach about 2.568 billion by 2040,which will seriously endanger human life and health.Huanglian Wendantang,as a famous traditional Chinese medicine prescription for clearing away heat and drying dampness,regulating Qi and resolving phlegm,and benefiting the stomach and gall,has been proved to have significant pharmacological effects in lowering blood fat,reducing blood sugar and resisting inflammation by modern pharmacological studies,and widely used in the treatment of metabolic diseases,cardiovascular diseases and other systemic diseases.In recent years,a large number of studies have proved that Huanglian Wendantang has a significant effect on MS.In terms of clinical efficacy,it could significantly improve the pathological state of obesity,dyslipidemia,abnormal glucose metabolism and hypertension in MS patients.Meanwhile,it could also interfere with the inflammatory state,prethrombotic state,abnormal vascular regulation and other potential risk factors in the body,with a high safety and fewer side effects.In terms of experimental study,it could enhance the insulin sensitivity,and improve the insulin resistance of MS animal models and cell models through interventions in insulin signal transduction,inflammatory response,and antioxidant stress.By retrieving PubMed,CNKI,Weipu,Wanfang and other databases,the author summarized the study reports of Huanglian Wendantang on MS in recent years in three aspects:theoretical study,clinical efficacy study and experimental mechanism study,in the expectation of provide some scientific references for in-depth study of the mechanism of Huanglian Wendantang in treating MS and the development and clinical promotion of the prescription.