抗带状疱疹疫苗进展

Progress in Vaccine Against Herpes Zoster

带状疱疹由长期潜伏在脊髓背根神经节或颅神经节中的水痘-带状疱疹病毒(varicella-zoster virus,VZV)再激活引起,最常见于老年人及免疫缺陷人群,其最常见的并发症是带状疱疹后神经痛(postherpetic neuralgia,PHN),对患者生活质量和日常生活活动有显著的不良影响。而预防潜伏的VZV再激活引起带状疱疹及其并发症的最佳策略是接种疫苗。随着人口老龄化和社会的不断发展,带状疱疹的发病率呈显著上升趋势,我国带状疱疹的防控形势需要更多的关注,疫苗的应用,将为带状疱疹及并发症的防控发挥重要作用。本文对抗带状疱疹疫苗的进展作一综述。

Herpes zoster is caused by the reactivation of varicella-zoster virus(VZV),which has long been latened in the dorsal root ganglia or cranial ganglia of the spinal cord.Herpes zoster is common in the elderly and immunocompromised population,its most common complication is postherpetic neuralgia(PHN),which has significant adverse effects on patientsr quality of life and daily activities.The best strategy to prevent latent VZV reactivation causing herpes zoster and its complication is vaccination.With the continuous development of the aging society,the incidence of herpes zoster is on the rise,further attention should be paid to the prevention and control of herpes zoster in China.The application of the vaccine will play an important role in the prevention and control of herpes zoster and its complication,this article reviews the progress in vaccine against herpes zoster.