基于正交试验方法的柔性神经电极优化设计

Optimization Design of Flexible Neural Electrodes Based on Orthogonal Experimental Method

对柔性神经电极进行优化设计,综合弹性模量、电极厚度、楔形角这3个参数进行研究,利用正交试验设计的思想设置试验组,采用ANSYS软件研究不同试验组的脑组织最大应变,并根据试验结果提出组合式柔性神经电极的设计思路.研究结果表明,在弹性模量为8.5 GPa、电极厚度为15μm、楔形角为45°的情况下,微动造成的脑组织最大应变最小,为5.5627×10-2.一种中间层聚合物弹性模量为5.5 GPa,两边层聚合物弹性模量为8.5 GPa的三明治结构的组合式柔性电极,在微动损伤以及植入形变上均具有一定的优势.

In order to optimize the design of flexible neural electrodes,three parameters of elastic modulus,electrode thickness,and wedge angle are comprehensively studied.The experimental groups are established based on orthogonal experimental design.The maximum strain of brain tissue in different experimental groups are evaluated by ANSYS.In addition,a new hybrid flexible electrode is designed based on the stimulation results.The experimental results reveal that when elastic modulus is 8.5GPa,thickness is 15μm and wedge angle is 45°,the maximum strain of brain tissue due to micromotion is the smallest,i.e.,5.5627×10-2.Moreover,a sandwich-type hybrid flexible neural electrode is designed with an elastic modulus of 8.5GPa on both sides and an elastic modulus of 5.5GPa in the intermediate layer.The sandwich-type structure can effectively reduce micromotion damage and implant deformation compared to the traditional electrode.