有氧联合抗阻运动对妇科肿瘤幸存者身体适能、癌因性疲乏和生活质量的影响

Efficacy of aerobic combined resistance exercise on physical fitness, cancer-related fatigue and quality of life in patients with gynecological cancer

目的:探讨12周有氧联合抗阻运动对妇科肿瘤患者身体适能、癌因性疲乏和生活质量等方面的影响。方法:选取25例宫颈癌及内膜癌患者,随机分为运动组(n=14)和对照组(n=11),运动组进行12周的有氧联合抗阻运动,对照组保持原有生活方式。在干预前后进行身体成分、心肺功能、肌肉力量测试并填写癌因性疲乏和生活质量问卷。结果:(1)运动组负荷运动时间、V02max和METS显著改善(P <0.05)。干预前后运动组负荷运动时间、VO2max和METS的差值显著高于对照组(P <0.05);(2)运动组肌肉质量显著增加,体脂率降低(P <0.01),体重和BMI显著下降(P <0.05)。干预前后运动组体脂率、肌肉含量的差值显著高于对照组(P <0.01);(3)运动组握力、30秒坐站显著提高(P <0.05)。干预前后运动组握力和30秒坐站的差值显著高于对照组(P <0.05);(4)运动组的疲乏总分显著降低(P <0.05)。干预前后运动组的总分显著高于对照组(P <0.01);(5)运动组躯体功能、角色功能、情绪功能、总体健康状况、疲乏、疼痛、呼吸困难和失眠显著改善(P <0.05);干预前后运动组的躯体功能显著高于对照组(P <0.01),角色功能、认知功能、社会功能、疲乏、呼吸困难、失眠和腹泻显著高于对照组(P <0.05)。结论:有氧联合抗阻运动能显著改善妇科肿瘤患者的心肺功能、身体成分、肌肉力量、癌因性疲乏生活质量。

Objective: To investigate the efficacy of 12-week aerobic combined resistance exercise on physical fitness, cancer-related fatigue and quality of life of patients with gynecological cancer. Methods: Twenty-five patients with cervical cancer and endometrial cancer were randomly divided into exercise group(n = 14)and control group(n = 11). The exercise group performed aerobic combined resistance exercise for 12 weeks, while the control group maintained the original lifestyle. Body composition, cardiopulmonary function, muscle strength cancer-related-fatigue and quality of life were tested before and after the intervention. Results:(1) The exercise time, V02 max and METS of the exercise group were significantly improved(P < 0.05). The difference between exercise time, VO2 max and METS in the exercise group before and after intervention was significantly higher than that in the control group(P < 0.05);(2) The muscle mass in the exercise group increased significantly, the body fat rate decreased(P < 0.01), and body weight and BMI decreased significantly(P< 0.05). The difference between body fat rate and muscle content in exercise group before and after intervention was significantly higher than that in control group(P < 0.01);(3) Grip strength and 30-second stand to stand in exercise group were significantly improved(P < 0.05). The difference between grip strength and 30-second 30-second stand to stand in the exercise group before and after intervention was significantly higher than that in the control group(P < 0.05);(4) The total fatigue score of the exercise group was significantly reduced(P < 0.05). The total score of the exercise group before and after intervention was significantly higher than that of the control group(P < 0.01);(5) The physical function, role function, emotional function, general health status, fatigue, pain, dyspnea and insomnia of the exercise group were significantly improved(P < 0.05);The physical function of the exercise group before and after intervention was significantly higher than that of the control group(P < 0.01), and the role function, cognitive function, social function, fatigue, dyspnea, insomnia and diarrhea were significantly higher than that of the control group(P < 0.05). Conclusion: Aerobic combined resistance exercise can significantly improve cardiopulmonary function, body composition, muscle strength, cancer-related fatigue and quality of life in patients with gynecological cancer.