依达拉奉联合丁苯酞序贯治疗急性脑梗死合并认知功能障碍的临床疗效

Clinical effect of edaravone combined with butylphthalide in sequential treatment of acute cerebral infarction complicated with cognitive dysfunction

目的探讨依达拉奉联合丁苯酞序贯治疗急性脑梗死合并认知功能障碍的临床疗效。方法选取龙岩人民医院2018年8月—2019年7月收治的急性脑梗死合并认知功能障碍患者67例,根据不同治疗方法分为对照组33例与研究组34例。对照组予以依达拉奉治疗,研究组在对照组治疗基础上予以丁苯酞序贯治疗。比较两组治疗前后美国国立卫生研究院脑卒中量表(NIHSS)评分、简易精神状态量表(MMSE)评分、蒙特利尔认知评估量表(MoCA)评分、白介素6(IL-6)、肿瘤坏死因子α(TNF-α)、神经元特异性烯醇化酶(NSE),临床疗效,并观察两组不良反应发生情况。结果治疗前两组NIHSS评分、MMSE评分、MoCA评分比较,差异无统计学意义(P>0.05);治疗后研究组NIHSS评分低于对照组,MMSE评分、MoCA评分高于对照组(P<0.05)。治疗前两组IL-6、TNF-α、NSE比较,差异无统计学意义(P>0.05);治疗后研究组IL-6、TNF-α、NSE低于对照组(P<0.05)。研究组临床疗效优于对照组(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论依达拉奉联合丁苯酞序贯治疗急性脑梗死合并认知功能障碍的临床疗效确切,可有效缓解患者神经功能缺损程度,改善认知功能,降低炎性反应,且安全性较高。

Objective To study the clinical effect of edaravone combined with butylphthalide in sequential treatment of acute cerebral infarction complicated with cognitive dysfunction.Methods A total of 67 cases of patients with acute cerebral infarction complicated with cognitive dysfunction were selected from August 2018 to July 2019 in Longyan People’s Hospital,which were divided into control group(n=33)and study group(n=34)according to different treatment methods.The control group was treated with edaravone,while the study group was treated with sequential treatment of butylphthalide on the basis of the control group.NIHSS score,MMSE score,MoCA score,IL-6,TNF-α,NSE before and after treatment,clinical effect were compared between the two groups,and the incidence of adverse reactions were observed.Results There was no significant difference in NIHSS score,MMSE score and MoCA score between the two groups before treatment(P>0.05);after treatment,the study group of NIHSS score was lower than control group,MMSE score and MoCA score were higher control group(P<0.05).There was no significant difference in IL-6,TNF-αand NSE between the two groups before treatment(P>0.05);after treatment,the study group of IL-6,TNF-αand NSE were lower than control group(P<0.05).The clinical effect of the study group was better than control group(P<0.05).There was no significant difference in the incidence rate of adverse reactions between the two groups(P>0.05).Conclusion Edaravone combined with sequential treatment of butylphthalide have an exact clinical effect for acute cerebral infarction complicated with cognitive dysfunction,which can effectively alleviate the degree of neurological deficit,improve cognitive function and reduce inflammatory reaction,and with high safety.