18F-FDG PET/CT评价初诊T细胞淋巴瘤代谢活性与免疫表型的相关性

18F-FDG PET/CT evaluation on correlation between metabolic activity and immunophenotype of newly diagnosed T cell lymphoma

目的观察初诊T细胞淋巴瘤18F-FDG代谢活性与淋巴瘤免疫表型的关系。方法回顾性分析64例初诊T细胞淋巴瘤患者,均于治疗前接受18F-FDG PET/CT检查且经病理学确诊。测量活检部位PET/CT最大标准摄取值(SUVmax),分析其与免疫表型之间的相关性。结果64例活检部位SUVmax为2.23~24.42,中位SUVmax为8.02,与Ki-67、CD5表达呈正相关(rs=0.31、P=0.02,rs=0.81、P<0.01),而与其他免疫学指标均无相关性(P均>0.05)。结论T细胞淋巴瘤代谢活性与Ki-67和CD5表达呈正相关;18F-FDG PET/CT可作为无创评估Ki-67和CD5免疫表达的影像学手段。

Objective To explore the relationship between metabolic activity on 18F-FDG and immunophenotype of newly diagnosed T cell lymphoma.Methods Data of 64 cases of newly diagnosed T cell lymphoma confirmed by pathology were retrospectively analyzed.All patients underwent PET/CT examination,and the detailed immunohistochemical results were obtained.ROI were drawn on PET/CT,and the maximum standardized uptake value(SUVmax)of biopsy site was measured.The correlation between SUVmax and immunophenotype was analyzed.Results The median SUVmax at biopsy-proven malignant lesions in 64 cases was 8.02(2.23-24.42).SUVmax of lesions was positively correlated with expression of Ki-67 and CD5(rs=0.31,P=0.02;rs=0.81,P<0.01),but not with other immunological factors(all P>0.05).Conclusion The metabolic activity of T cell lymphoma lesions on 18F-FDG are related to the expression of Ki-67 and CD5.18F-FDG can be used as an imaging method for noninvasive evaluation on expression of Ki-67 and CD5.