壳聚糖卵磷脂对MCI患者听觉注意P300的影响

The effect of Chitosan Lecithin on auditory P300 of MCI patients

目的探讨壳聚糖卵磷脂对轻度认知功能障碍(MCI)患者听觉注意P300的影响。方法采用配对设计,将入选的40例MCI患者分为观察组和对照组,各20例,观察组口服壳聚糖卵磷脂,对照组口服等剂量安慰剂,干预时间2个月。使用美国Neuroscan公司生产的ERP系统,采用新异Oddball识别模式,观察干预前后ERP P300成分的变化。结果①干预后观察组患者的反应时较对照组明显缩短(P<0.05),②取Fz,Cz,Pz 3个电极波幅及潜伏期的平均值,干预后观察组Cz,Pz电极P3a波幅较对照组增大(P<0.05),Fz,Cz电极P3b潜伏期较对照组明显缩短(P<0.05)。结论壳聚糖卵磷脂可以提高MCI患者的听觉注意能力,改善患者的认知功能。

Objective To explore the effect of Chitosan Lecithin on auditory attention P300 in patients with mild cognitive impairment(MCI).Methods Paired design was used to divide the 40 selected MCI patients into an observation group and a control group,20 cases each.The observation group were given Chitosan Lecithin,while the control group were given the same dose of placebo for two months.With US Neuroscan event-related potential(ERP) system,the change of ERP P300 of MCI patients was analyzed by novel-oddball test.Results ①Compared with the control group,the reaction time was significantly shorter(P<0.05) after intervention.②Taking the average amplitude and latency of Fz,Cz and Pz electrodes,compared with the control group,the amplitude of P3 a in Cz and Pz was increased(P<0.05),and the latency of P3 b in Fz and Cz was significantly shorter after intervention(P<0.05).Conclusion Chitosan Lecithin can enhance the MCI patients’ ability of auditory attention and improve the patients’ cognitive function.