摘要
心力衰竭是一种复杂的临床综合征,严重危害人类健康。随着对心力衰竭的不断深入研究,人们发现生物标志物在心力衰竭、尤其是在射血分数保留的心力衰竭(HFpEF)中扮演着越来越重要的角色。不同途径(包括神经激素激活、心肌损伤、炎症和纤维化等)的生物标志物对HFpEF具有超出诊断范围的临床效用。本文主要对钠尿肽和新型生物标志物如乳糖凝集素-3及转化生长因子-15等在HFpEF患者诊断及预后中的研究进展进行综述。
Heart failure is a complex clinical syndrome that seriously harms human health.The deepening studies found biomarkers play an increasingly important role in the field of heart failure,especially in heart failure with preserved ejection fraction(HFpEF).Biomarkers of different pathways(including neurohormone activation,myocardial injury,inflammation and fibrosis)have clinical effects beyond the diagnostic range for HFpEF.This article reviews the advances of natriuretic peptide and new biomarkers(lactose agglutinin-3 and growth differentiation factor-15)in the diagnosis and prognosis of HFpEF patients.
作者
李甜甜
郭丽
张书虎
LI Tian-Tian;GUO Li;ZHANG Shu-Hu(Department of Cardiology, First Affiliated Hospital of Jiamusi University, Jiamusi 154002, Heilongjiang Province, China;Department of Geriatrics, Second Affiliated Hospital of Harbin Medical University, Harbin 150086, Heilongjiang Province, China)
出处
《中华老年多器官疾病杂志》
2020年第8期622-625,共4页
Chinese Journal of Multiple Organ Diseases in the Elderly
关键词
心力衰竭
射血分数保留
生物标志物
诊断
预后
heart failure,preserved ejection fraction
biomarker
diagnosis
prognosis
