叶酸联合甲钴胺对H型高血压患者血压控制的临床效果及生化指标的影响

Clinical Effects of Folic Acid Combined with Methylcobalamin on Blood Pressure Control and the Effects on Biochemical Indexes of Patients with H-Type Hypertension

目的探讨叶酸联合甲钴胺对H型高血压患者血压控制的临床效果及生化指标的影响。方法选取2018年2月至2019年10月在辽宁省金秋医院接受治疗的H型高血压患者154例作为研究对象,依据随机数字表法分为对照组与观察组,各77例。两组均予以常规降压药物,帮助患者的血压保持在稳定状态。对照组另予以甲钴胺治疗,观察组则在对照组治疗基础上增用叶酸,比较两组治疗前及治疗2个月后的收缩压(SBP)、舒张压(DBP)、同型半胱氨酸(Hcy)、一氧化氮(NO)及不良反应发生情况。结果治疗后两组的SBP和DBP较治疗前下降,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗后两组的血清Hcy明显下降,而NO明显升高,观察组改变较对照组更大,差异有统计学意义(P<0.05)。观察组不良反应发生率为7.79%,与对照组的3.90%比较,差异无统计学意义(P>0.05)。结论叶酸联合甲钴胺能够有效提升H型高血压患者的血压控制效果,优化其机体生化指标,安全性较好。

Objective To explore the clinical effects of folic acid combined with methylcobalamin on blood pressure control and the effects on biochemical indexes of H-type hypertension patients. Methods A total of 154 patients in General Geriatric Department, Jinqiu Hospital, Liaoning Province, with H-type hypertension were selected as the research subjects from February 2018 to October 2019 and were divided into an observation group and a control group according to random number table method,with 77 cases in each group. Both groups were given regular antihypertensive drugs to help patients’ blood pressure remain stable. The control group was treated with methylcobalamin, while the observation group was treated with methylcobalamin and folic acid on the basis of the control group. The systolic blood pressure(SBP) and diastolic blood pressure(DBP), serum homocysteine(Hcy) and nitric oxide(NO), and adverse effects were compared between the 2 groups before and after 2 months of treatment. Results The SBP and DBP of the 2 groups after treatment were lower than those before treatment, and the observation group was lower than the control group and the difference was statistically significant(P<0.05). The serum Hcy of the 2 groups after treatment was significantly lower than before treatment, while the NO was significantly higher than before treatment, and the observation group was higher than the control group, and the difference was statistically significant(P<0.05).The total incidence of adverse reactions in the observation group was 7.79%, which was not statistically different compared with 3.90% in the control group(P>0.05). Conclusion Folic acid combined with methylcobalamin can effectively improve the blood pressure control effects of H-type hypertension patients, optimize its body biochemical index, with good safety.