角蛋白在肿瘤诊断及预后中的应用

Application of keratins in cancer diagnosis and prognosis

角蛋白是上皮细胞的骨架蛋白,可参与调控肿瘤细胞的凋亡耐受、生长及迁移,与肿瘤发生密切相关。有的角蛋白在肿瘤患者血清中的水平升高或高表达于肿瘤组织中,在临床上被广泛用于肿瘤的诊断;有的角蛋白的表达与肿瘤患者预后呈负相关,可作为肿瘤预后标志物。进一步阐明角蛋白联合其他标志物检测对肿瘤诊断及预后判断的价值,将为角蛋白应用于临床肿瘤诊断与预后评估提供理论依据。

Keratins are cytoskeleton proteins,which are involved in apoptotic resistance,growth and migration of cancer cells.The levels of some keratins are elevated in the serum of patients with cancers,or highly expressed in cancer tissues,and they are widely used in the diagnosis of tumor in clinic.The expressions of some keratins are negatively correlated with the prognosis of patients with cancers,and can be used as prognostic markers.Further clarifying the diagnostic and prognostic value of keratins combined with other markers detection can provide theoretical basis for the application of keratins in diagnosis and prognostic assessment of cancers.