干扰素治疗肿瘤相关的信号通路及临床应用

Interferon-related signaling pathways and clinical application in tumor therapy

Ⅰ、Ⅱ、Ⅲ型干扰素虽都具有抗肿瘤潜能,但作用机制和临床疗效有所不同。与干扰素治疗肿瘤相关的信号通路主要包括JAK-STAT、PI3K/AKT/mTOR、MAPK、NF-κB、c-Abl等。目前Ⅰ型干扰素临床应用最广,疗效最明确;Ⅱ型干扰素因存在严重的不良反应且可能在诱导癌变过程中发挥作用,对其是否可以用于抗肿瘤治疗存在较大争议;Ⅲ型干扰素虽在生物学功能上兼备了Ⅰ、Ⅱ型干扰素的优良特点,但其对抗肿瘤的药用价值还有待进一步评估。

TypeⅠ,Ⅱ,Ⅲinterferons have anti-tumor potential,but the mechanism of action and clinical effect are different.Signaling pathways associated with interferon-treated tumors mainly include JAK-STAT,PI3K/AKT/mTOR,MAPK,NF-κB,c-Abl,etc.TypeⅠinterferon has the widest clinical application and the most definite curative effect at present.Because of its serious adverse reaction and possible role in the process of cancer induction,typeⅡinterferon has a great controversy on whether it can be used in anti-tumor therapy.The biological function of typeⅢinterferon has good characteristics of typeⅠandⅡinterferon,but its anti-tumor medicinal value needs to be further evaluated.