二甲双胍联合饮食疗法治疗社区糖尿病患者的临床效果分析

Clinical effect of metformin combined with dietotherapy in the treatment of community diabetes patients

目的:探讨二甲双胍联合饮食疗法治疗社区糖尿病患者的临床效果。方法:2018年5月-2019年5月收治糖尿病患者82例,随机分为两组,各41例。对照组给予二甲双胍治疗;观察组在二甲双胍基础上联合饮食疗法治疗。比较两组血糖及胰岛素指标水平。结果:观察组治疗后糖化血红蛋白(HbA1c)、空腹血糖(FPG)及餐后2 h(2 hPG)血糖水平均低于对照组,差异有统计学意义(P<0.05);观察组治疗后胰岛素抵抗指数(HOMA-IR)及空腹胰岛素(FINS)水平均低于对照组,胰岛β细胞功能指数(HOMA-β)高于对照组,差异均有统计学意义(P<0.05)。结论:二甲双胍联合饮食疗法治疗社区糖尿病,可降低患者血糖水平,提高糖胰岛β细胞分泌量,降低胰岛素抵抗能力,改善患者饮食习惯。

Objective:To explore the clinical effect of metformin combined with dietotherapy in the treatment of community diabetes patients.Methods:From May 2018 to May 2019,82 diabetic patients were selected and randomly divided into two groups of 41 cases in each.The control group was treated with metformin.The observation group was treated with metformin combined with dietotherapy.We compared the blood glucose and insulin levels between the two groups.Results:In the observation group,after treatment,glycosylated hemoglobin,fasting blood glucose and 2 hours postprandial blood glucose were lower than those in the control group,the difference was statistically significant(P<0.05).In the observation group,after treatment,the insulin resistance index and fasting insulin level were lower than those in the control group,and theβcell function index was higher than that in the control group,the difference was statistically significant(P<0.05).Conclusion:The application of metformin combined with dietotherapy in the treatment of community diabetes patients can reduce the blood glucose level,increase the secretion ofβcell,reduce the insulin resistance and improve the diet habit of patients.