生化检验在肝硬化疾病诊断中的临床价值观察

Observation of the clinical value of biochemical tests in the diagnosis of liver cirrhosis

目的探讨生化检验项目在肝硬化疾病诊断中的临床效果。方法选取145例肝炎后肝硬化患者作为肝炎后肝硬化组,同期95例酒精性肝硬化患者作为酒精性肝硬化组。两组患者均接受生化检验以及血常规检验。比较两组患者生化检验指标[丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、天门冬氨酸氨基转移酶/丙氨酸氨基转移酶(AST/ALT)、总胆红素(TBIL)、γ-谷氨酰转肽酶(GGT)、碱性磷酸酶(ALP)]、血常规检验指标[白细胞计数(WBC)、中性粒细胞绝对值、淋巴细胞绝对值、中性粒细胞/淋巴细胞、血红蛋白、平均红细胞体积(MCV)]水平。结果肝炎后肝硬化组患者ALT(102.20±24.50)U/L、AST(104.15±25.45)U/L高于酒精性肝硬化组的(50.10±12.35)、(77.30±15.35)U/L,AST/ALT(1.30±1.45)、TBIL(42.50±12.50)μmol/L、GGT(107.30±28.30)U/L、ALP(105.50±65.30)U/L低于酒精性肝硬化组的(2.30±1.05)、(89.25±25.65)μmol/L、(179.30±32.45)U/L、(144.85±75.50)U/L,差异具有统计学意义(P<0.05)。两组患者淋巴细胞绝对值、血红蛋白水平比较差异无统计学意义(P>0.05);肝炎后肝硬化组患者WBC(4.50±1.03)×10^9/L、中性粒细胞绝对值(2.60±0.84)×10^9/L、中性粒细胞/淋巴细胞(2.60±0.36)、MCV(88.25±15.05)fl均低于酒精性肝硬化组的(6.35±1.95)×10^9/L、(4.10±1.08)×10^9/L、(3.30±0.90)、(96.50±14.05)fl,差异具有统计学意义(P<0.05)。结论在肝硬化疾病诊断中采用生化检验可为临床诊断提供依据。

Objective To discuss the clinical effect of biochemical tests in the diagnosis of liver cirrhosis.Methods There were 145 patients with post-hepatitis cirrhosis as the post-hepatitis cirrhosis group,and 95 patients with alcoholic cirrhosis in the same period as the alcoholic cirrhosis group.Both groups received biochemical test and blood routine test.The biochemical tests indicators[alanine aminotransferase(ALT),aspartate aminotransferase(AST),AST/ALT,total bilirubin(TBIL),γ-glutamyl transpeptidase(GGT),alkaline phosphatase(ALP)],blood routine indicators[white blood cell(WBC)count,neutrophil absolute value,lymphocyte absolute value,neutrophil/lymphocyte,hemoglobin,mean corpuscular volume(MCV)]were compared between the two groups.Results ALT(102.20±24.50)U/L and AST(104.15±25.45)U/L of post-hepatitis cirrhosis group was higher than that of alcoholic cirrhosis group(50.10±12.35)and(77.30±15.35)U/L,and AST/ALT(1.30±1.45),TBIL(107.30±28.30)μmol/L,GGT(42.50±12.50)U/L and ALP(105.50±65.30)U/L was lower than that of alcoholic cirrhosis group(2.30±1.05),(89.25±25.65)μmol/L,(179.30±32.45)U/L and(144.85±75.50)U/L,and the difference was statistically significant(P<0.05).There was no statistically significant difference in lymphocyte absolute value and hemoglobin level between the two groups(P>0.05).WBC(4.50±1.03)×10^9/L,neutrophil absolute value(2.60±0.84)×10^9/L,neutrophil/lymphocyte(2.60±0.36)and MCV(88.25±15.05)fl of post-hepatitis cirrhosis group was lower than that of alcoholic cirrhosis group(6.35±1.95)×10^9/L,(4.10±1.08)×10^9/L,(3.30±0.90)and(96.50±14.05)fl,and the difference was statistically significant(P<0.05).Conclusion Biochemical tests can provide basis for diagnosis of liver cirrhosis.