孕早期补体水平与子痫前期的相关性研究

Correlation between the level of complement in early pregnancy and preeclampsia

目的探讨孕早期补体水平与子痫前期的相关性。方法收集来自绍兴市妇幼保健院2017年1月~2018年12月的孕妇标本,未患子痫前期孕妇88例,子痫前期孕妇76例,比较两组孕妇在孕早期基础数据和补体水平(C1q、C3、C4和B因子)的差异,并采用多因素非条件Logistic回归分析模型找出影响子痫前期发生的独立危险因素。结果两组孕妇比较发现肥胖、慢性高血压、双胎、C1q和B因子之间差异有统计学意义(P<0.05),年龄、初产妇数比例、产前BMI、孕次、产次、收缩压、舒张压、脉压差、心率、2型糖尿病、肾脏疾病、C3和C4等指标差异无统计学意义(P>0.05)。多因素非条件Logistic回归分析模型结果显示,慢性高血压和B因子是诊断和监测子痫前期的独立危险因素(均P<0.05)。结论孕早期,血清C1q和B因子会发生明显降低,同时B因子可以作为辅助诊断子痫前期发生的潜在指标。

Objective To explore the correlation between the level of complement in early pregnancy and preeclampsia.Methods Pregnant women specimens from Shaoxing Maternal and Child Health Hospital from January 2017 to December 2018 were collected.There were 88 pregnant women without preeclampsia and 76 pregnant women with preeclampsia.The differences in basic data and complement levels(C1q,C3,C4,and B factors)of pregnant women in the early pregnancy were compared.Multivariate unconditional logistic regression analysis models were used to identify independent risk factors affecting preeclampsia.Results There was a statistically significant difference in obesity,chronic hypertension,twins,C1q and B factors between the two groups of pregnant women(P<0.05).There were no significant differences in age,primipara ratio,prenatal BMI,the number of pregnancy and birth,systolic blood pressure,diastolic blood pressure,pulse pressure difference,heart rate,type 2 diabetes,kidney disease,C3 and C4 between two groups(P>0.05).Multivariate unconditional logistic regression analysis showed that chronic hypertension and factor B were independent risk factors for diagnosis and monitoring of preeclampsia(P<0.05).Conclusion In the early pregnancy,serum C1q and factor B will be significantly reduced.Factor B can be used as a potential indicator to aid in the diagnosis of preeclampsia.