炔雌醇醋酸环丙孕酮与去氧孕烯炔雌醇治疗多囊卵巢综合征患者的效果比较

Comparison of effects of Ethinylestradiol cyproterone acetate and Desogestrel ethinylestradiol in treatment of patients with polycystic ovary syndrome

目的:比较炔雌醇醋酸环丙孕酮与去氧孕烯炔雌醇治疗多囊卵巢综合征患者的效果。方法:选取该院收治的90例多囊卵巢综合征患者为研究对象,按照随机数字表法分为对照组和观察组,每组45例。观察组给予炔雌醇醋酸环丙孕酮治疗,对照组给予去氧孕烯炔雌醇治疗。比较两组月经情况评分,体质量指数(BMI),激素、胰岛素抵抗指数(HOMA-IR)、空腹血糖(FBG)、空腹胰岛素(FINS)和血脂指标水平,以及排卵率与不良反应发生率。结果:治疗后,两组月经情况评分和BMI均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后,观察组促黄体生成激素(LH)、促卵泡生成激素(FSH)、LH/FSH、睾酮,FBG、FINS、HOMA-IR和总胆固醇(TC)、三酰甘油(TG)水平均低于对照组,差异有统计学意义(P<0.05);观察组排卵率为73.33%,高于对照组的51.11%,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:相较于去氧孕烯炔雌醇,炔雌醇醋酸环丙孕酮治疗多囊卵巢综合征患者可降低月经情况评分、BMI、HOMA-IR、性激素水平、FBG水平、FINS水平和血脂指标水平,以及提高排卵率。

Objective:To compare effects of Ethinylestradiol cyproterone acetate and Desogestrel ethinylestradiol in treatment of patients with polycystic ovary syndrome.Methods:90 patients with polycystic ovary syndrome admitted to the hospital were selected as the research objects,and were divided into control group and observation group according to the random number table,45 cases in each group.The observation group was treated with Ethinylestradiol cyproterone acetate,while the control group was treated with Desogestrel ethinylestradiol.Then,the menstrual status scores,body mass index(BMI),hormone levels,insulin resistance index(HOMA-IR),fasting blood glucose,fasting insulin and blood lipid levels,the ovulation rate and the incidence of adverse reactions were compared between the two groups.Results:After the treatment,the menstrual status score and BMI of the two groups were lower than those before the treatment;those of the observation group were lower than those of the control group;and the differences were statistically significant(P<0.05).After the treatment,the levels of luteinizing hormone(LH),follitropin(FSH),LH/FSH,testosterone,fasting blood glucose(FBG),fasting insulin(FINS),HOMA-IR and blood lipid indexes[total cholesterol(TC)and triglyceride(TG)]of the observation group were lower than those of the control group,and the differences were statistically significant(P<0.05).The ovulation rate in the observation group was 73.33%,which was higher than 51.11%in the control group,and the difference was statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Compared with Desogestrel ethinylestradiol,Ethinylestradiol cyproterone acetate in the treatment of the patients with polycystic ovary syndrome can reduce the menstrual status scores,the body mass index and the levels of insulin resistance index,sex hormone,fasting blood glucose,fasting insulin and blood lipid,and increase the ovulation rate.