摘要
过氧化物酶体增殖物激活受体(peroxisome proliferator-activated receptors,PPARs)是1990年发现的核受体超家族的成员,迄今为止共发现了3种PPARs(α、β/δ和γ)。PPARs主要在肝、脂肪、心肌等组织表达,发挥促进脂肪酸摄取、转运和氧化,参与能量代谢平衡的功能[1]。心力衰竭(简称"心衰")时心脏重塑的机制与能量稳态直接相关[2],随着糖尿病、高血压等代谢性疾病所致慢性心衰的发病率逐年上升,代谢调控在心衰治疗中的作用受到了广泛关注[3-4]。
Peroxisome proliferator-activated receptors(PPARs)are important nuclear receptors that act as transcriptional regulators of glucose metabolism and lipid metabolism. Recent studies have shown that myocardial PPARs affect the progression of heart failure by regulating pathophysiological processes such as metabolism,oxidative stress and fibrosis. This article will discuss the progress in effects of PPARs on 3 types of heart failure:hypertensive heart failure,ischemic heart failure and diabetic heart failure.
作者
张健维
徐坦
徐明
ZHANG Jian-wei;XU Tan;XU Ming(Department of Cardiology and Institute of Vascular Medicine,Peking University Third Hospital,Key Laboratory of Cardio-vascular Molecular Biology and Regulatory Peptides,Ministry of Health,Key Laboratory of Molecular Cardiovascular Science,Ministry of Education,Beijing 100191,China)
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2020年第8期1509-1514,共6页
Chinese Journal of Pathophysiology
基金
国家自然科学基金资助项目(No.81625001,No.91339105)
国家重点研发计划(No.2018YFC1312700,No.2018YFC1312701)。
关键词
过氧化物酶体增殖物激活受体
心力衰竭
代谢
氧化应激
Peroxisome proliferator-activated receptors
Heart failure
Metabolism
Oxidative stress
