婴幼儿肠道菌群与维生素K研究进展

Research progress on intestinal flora and Vitamin K in infants and young children

一般情况下,婴幼儿自身与其肠道菌群处于和谐、相互依存、相互制约的状态。人体所需的大部分维生素K主要由肠道菌群合成,肠道菌群失衡会导致维生素K依赖性凝血因子减少,易引起消化道继发性出血。另外,近年来,来自肠道菌群的维生素K与骨代谢的关联性引起了人们的广泛关注。通过调节肠道菌群以促进骨骼健康,抑制骨钙流失,为儿童佝偻病和其他骨代谢疾病提供新的治疗思路,是当前研究的热点之一。然而,肠道微生物种类繁多,数量庞大,不同菌种对人体肠道和健康的影响机理有待进一步研究,肠道菌群、维生素K与骨代谢的相关性还需在大样本、前瞻性研究中进一步探索。

In a normal healthy state,infants themselves and their intestinal flora are in a state of harmony,interdependence and mutual restriction.Most of the vitamin K required by human body is mainly synthesized by intestinal flora.If intestinal flora is unbalanced,vitamin K-dependent coagulation factors will be reduced,which will easily lead to secondary gastrointestinal bleeding.In addition,in recent years,the correlation between vitamin K from intestinal flora and bone metabolism has attracted much attention.Regulating intestinal flora to promote bone health,inhibit bone calcium loss,and provide new targeted therapy for children with rickets and other bone metabolic diseases,it is one of the current research hotspots.However,there are a large number of intestinal microbes,and the mechanism of different strains’ influence on the human intestinal tract and health needs to be further studied.The correlation between intestinal flora,vitamin K and bone metabolism needs to be further explored in a large sample and prospective studies.