支气管镜下肺泡灌洗治疗肺癌合并肺部感染患者的疗效观察

Efficacy of bronchoscopic alveolar lavage in the treatment of lung cancer complicated with an infection

目的探讨支气管镜下肺泡灌洗治疗肺癌合并肺部感染的临床效果。方法选取2017年2月至2019年12月间河南省人民医院收治的80例肺癌合并肺部感染患者。根据治疗方法不同进行分组,其中,采用常规治疗的40例患者纳入对照组,在常规治疗基础上使用支气管镜下肺泡灌洗的40例患者纳入观察组。比较两组临床效果、痰液标本细菌培养转阴率,检测治疗前后血清高敏C反应蛋白(hs-CRP)、肿瘤坏死因子-a(TNF-a)、白细胞介素-8(IL-8)和降钙素原(PCT)水平。结果观察组临床总有效率为95. 0%,高于对照组的70. 0%,差异有统计学意义(P <0. 05)。观察组细菌培养转阴率90. 9%,高于对照组的64. 5%,差异有统计学意义(P <0. 05)。治疗前,两组患者hs-CRP、TNF-a、IL-8和PCT水平比较,差异无统计学意义(P> 0. 05),治疗后,两组患者hs-CRP、TNF-a、IL-8和PCT水平均降低,观察组低于对照组,差异均有统计学意义(均P <0. 05)。结论支气管镜下肺泡灌洗治疗肺癌合并肺部感染效果显著,提升痰液标本细菌培养转阴率,抑制炎症因子水平,具有临床推广价值。

Objective To explore the clinical effect of bronchoscopic alveolar lavage in the treatment of lung cancer with an infection. Methods A total of 80 patients with lung cancer and an infection admitted to Henan People’s Hospital from February 2017 to December 2019 were selected and divided into groups based on the treatment they received. The observation group received bronchoscopic alveolar lavage apart from the conventional treatment and the control group received conventional treatment with 40 patients in each group. Clinical efficacy and the sputum conversion rate( SCR) were compared between the two groups and the levels of serum high sensitive C-reactive protein( hs-CRP),tumor necrosis factor-a( TNFa),interleukin-8( IL-8) and procalcitonin( PCT) were detected before and after the treatment. Results The overall clinical efficacy rate was 95. 0% in the observation group which was significantly higher than70. 0% of the control group( P < 0. 05). SCR was 90. 9% in the observation group which was significantly higher than 64. 5% of the control group( P < 0. 05). Difference in the levels of hs-CRP,TNF-a,IL-8,and PCT were not significant before the treatment between the two groups( P > 0. 05). However,after the treatment,the levels of hs-CRP,TNF-a,IL-8,and PCT decreased in both groups with the observation group lower than the control group( all P < 0. 05). Conclusion Bronchoscopic alveolar lavage has a significant efficacy in the treatment of lung cancer complicated with an infection. It can increase the sputum conversion rate and inhibit the level of inflammatory factors,which is worthy of clinical promotion.