与肺动脉高压相关的miRNA的研究进展

MicroRNA in pulmonary hypertension

肺动脉高压(PH)是一类以肺血管阻力进行性增加、右心功能进行性衰竭为特征的慢性致死性疾病,其主要病理变化是肺血管重塑。微小RNA(microRNA)是一类存在于真核细胞内、长度约为21~25 nt的内源性非编码RNA,可以在转录和翻译水平调控基因的表达,参与机体很多病理及生理过程。本文通过研究microRNA的表达与PH发生发展之间的关系,找寻潜在的PH早期诊断标志物,为PH的临床诊疗提供新的思路。

Pulmonary hypertension(PH)is a chronic fatal disease characterized by progressive increase of pulmonary vascular resistance and progressive failure of right heart function,and its main pathological change is pulmonary vascular remodeling.MicroRNA is a type of endogenous non-coding RNA existing in eukaryotic cells with a length of about 21-25 nucleotides.It can regulate gene expression through transcription and translation and participate in many pathological and physiological processes.By studying the relationship between the expression of microRNA and the occurrence and development of PH,this paper looks for potential early diagnostic markers of PH and provides new ideas for clinical diagnosis and treatment of PH.