丙戊酸镁联合齐拉西酮治疗双相情感障碍的效果及对血清总胆红素白蛋白炎症因子水平的影响

Efficacy of Valproic Acid Combined with Ziprasidone on Bipolar Disorder and Its Effect on Serum Total Bilirubin Albumin and Inflammatory Factors

目的:研究丙戊酸镁联合齐拉西酮治疗双相情感障碍的效果及对血清总胆红素、白蛋白、炎症因子水平的影响。方法:选取我院于2014年10月至2016年10月收治的90例双相情感障碍患者,随机(随机数表法)分为治疗组(n=45)和对照组(n=45)。对照组采取丙戊酸镁治疗,治疗组则联合齐拉西酮治疗。观察比较两组患者临床治疗效果、血清白蛋白、总胆红素以及炎症因子水平变化情况、狂躁量表、汉密尔顿抑郁量表以及生活质量各维度评分情况以及安全性。结果:治疗后,治疗组患者的总有效率(93.33%)与对照组患者总有效率(77.78%)相比数据差异明显(P<0.05)。治疗组患者总胆红素和血清白蛋白明显升高,而炎症因子水平则明显降低,且其改善水平与对照组相比更为明显(P<0.05)。两组患者汉密尔顿抑郁量表和狂躁量表评分均明显下降,而生活质量评分则明显升高,且治疗组患者汉密尔顿抑郁量表、狂躁量表以及生活质量评分改善情况显著优于对照组(P<0.05)。结论:丙戊酸镁联合齐拉西酮用于治疗双相情感障碍的临床治疗效果甚佳,不仅能够显著降低患者汉密尔顿抑郁量表和狂躁量表评分,而且对血清总胆红素、白蛋白、炎症因子水平有一定的改善作用,同时不良反应较少,安全可靠。

Objective:To study clinical evaluation of magnesium valproate sustained release tablets combined with ziprasidone in treatment of bipolar disorder and effect on serum total bilirubin,albumin and inflammatory factors.Methods:90 cases with bipolar disorder from October 2014 to October 2016 in our hospital were researched,and according to the random number table they were divided into treatment group and control group,45 cases in each.Magnesium valproate sustained release tablet was administered to the control group,while the observation group was treated with magnesium valproate sustained release tablets combined with ziprasidone.They were compared on clinical treatment effect,serum albumin,total bilirubin and inflammatory factor levels,score of BRMS,Quality of Life and HAMD and safety.Results:After treatment,the difference between the total effective rate in treatment group(93.33%)and the total effective rate in the control group(77.78%)was statistically significant(P<0.05).The levels of serum albumin and total bilirubin in the treatment group were significantly higher than those in the control group(P<0.05),while the levels of inflammatory factors were significantly lower in the treatment group than in the control group(P<0.05).Scores of BRMS and HAMD in both groups were significantly decreased,while the life quality score was significantly increased,and the improvement of mania scale,Hamilton depression scale and life quality score in the treatment group was significantly better than that in the control group(P<0.05).Conclusion:The efficacy of magnesium valproate sustained release tablets combined with ziprasidone in the treatment of bipolar disorder was significant in reducing the score of BRMS and HAMD and improving serum total bilirubin,albumin,inflammatory factor levels,and it has less adverse reactions,being safe and reliable.