匹伐他汀对冠心病患者血糖影响的研究进展

Effect of Pivastatin on Blood Glucose in Patients with Coronary Heart Disease

随着他汀类药物在冠心病预防中地位不断提高,其所带来的不良影响越来越受到关注,有研究指出他汀类药物会影响糖代谢,甚至导致新发糖尿病发病率升高,匹伐他汀作为新一代人工合成的羟甲基戊二酸单酰辅酶A还原酶抑制剂,自上市以来其疗效和安全性备受关注,其对血糖的影响结论不一,有研究表明其对糖代谢无明显影响,甚至有积极作用,也有研究指出其影响糖代谢,但新发糖尿病发病率相对较低。现针对匹伐他汀对冠心病患者的血糖影响和作用机制进行系统性综述。

As statins continue to play an important role in the prevention of coronary heart disease,the adverse effects of statins have attracted more and more attention.Several studies have shown that statins affect glucose metabolism and even lead to an increase in the rate of new-onset diabetes.As a new generation of synthetic HMG-CoA reductase inhibitors,pivastatin has been paid much attention to its efficacy and safety since its marketing.The results of the study on the effect and mechanism of pivastatin on blood glucose are different,and there is no uniform conclusion.Some studies have shown that it has no obvious effect on sugar metabolism,even positive effect.Some studies have also pointed out that it affects sugar metabolism,but the rate of new-onset diabetes is relatively low.The effect and mechanism of pivastatin on blood glucose in patients with coronary heart disease were systematically reviewed in this article.