摘要
The number of patients with dementia is estimated to be as high as 24 million and is predicted to double every 20 years,i.e.,by 2040,leading to a tremendous financial disease burden[1].Therefore,we urgently need to identify drugs that can prevent,delay the onset,slow the progression,or improve the symptoms of Alzheimer's disease(AD).Drug development for AD has proven to be extremely difficult[2].