双合枣仁颗粒治疗抑郁性睡眠障碍阴虚火旺证40例临床观察

Clinical observation on Shuanghe Zaoren Keli(双合枣仁颗粒)in the treatment of 40 cases of depressive somnipathy with yin deficiency and effulgent fire syndrome

目的观察双合枣仁颗粒治疗抑郁性睡眠障碍阴虚火旺证的临床疗效。方法将80例抑郁性睡眠障碍阴虚火旺证患者采用随机数字表法分为治疗组和对照组,各40例。治疗组口服双合枣仁颗粒,对照组口服艾司唑仑片。2组均以连续治疗2周为1个疗程,1个疗程后比较2组治疗前后的总睡眠时间(TST)、实际总睡眠时间(TSA)、睡眠潜伏期(SL)、实际醒觉时间(AWT)、快速眼动睡眠期(REM)、快速眼动睡眠潜伏期(RL)、REM周期数(NRP)、REM睡眠比(R/T)、睡眠效率(SE)等睡眠视频脑电图参数及匹兹堡睡眠质量指数量表(PSQI)、汉密尔顿抑郁量表(HAMD)评分。结果治疗后2组SL、AWT、REM、NRP均缩短,R/T降低,TSA、RL均延长,SE提高,与同组治疗前比较差异有统计学意义(P<0.05),且治疗组以上各项指标改善更明显,与对照组治疗后比较差异均有统计学意义(P<0.05);治疗后2组PSQI、HAMD评分均明显降低,与同组治疗前比较差异有统计学意义(P<0.05),且治疗组降低更明显,与对照组治疗后比较差异有统计学意义(P<0.05)。结论双合枣仁颗粒治疗抑郁性睡眠障碍阴虚火旺证临床疗效显著,可明显缩短患者的AWT,延长TSA,改善睡眠结构,提高睡眠质量,值得临床推广应用。

Objective To observe the clinical efficacy of Shuanghe Zaoren Keli(双合枣仁颗粒)in the treatment of depressive somnipathy with yin deficiency and effulgent fire syndrome.Methods Eighty cases with depressive somnipathy with yin deficiency and effulgent fire syndrome were divided into treatment group and control group according to random number table method,with 40 cases in each.The treatment group was given oral Shuanghe Zaoren Keli,while the control group was given oral estazolam tablets.The 2 groups were both given consecutive treatment for 2 weeks as 1 course of treatment.After 1 course of treatment,total sleep time(TST),actual total sleep time(TSA),sleep latency(SL),actual waking time(AWT),rapid eye movement sleep period(REM),rapid eye movement sleep latency(RL),number of REM period(NRP),REM sleep ratio(R/T),sleep efficiency(SE)etc.sleep video EEG parameter and Pittsburgh sleep quality index(PSQI)scale and Hamilton depression(HAMD)scale of the 2 groups before and after treatment were compared.Results After treatment,SL,AWT,REM and NRP of the 2 groups all significantly shortened,R/T decreased,TSA and RL prolonged,SE increased,and the difference was statistically significant compared with the same group before treatment(P<0.05),moreover,the above-mentioned various index of the treatment group improved more significantly,and the difference was statistically significant compared with the control group after treatment(P<0.05).After treatment,scores of PSQI and HAMD of the 2 groups all significantly decreased,and the difference was statistically significant compared with the same group before treatment(P<0.05),moreover,the treatment group decreased more significantly,and the difference was statistically significant compared with the control group after treatment(P<0.05).Conclusion It has significant clinical efficacy and can markedly shorten AWT,prolong TSA,improve sleep structure and quality of the patients to use Shuanghe Zaoren Keli in the treatment of depressive somnipathy with yin deficiency and effulgent fire syndrome,which deserves clinical promotion and application.