食管鳞癌组织中TNFAIP3的表达及其预后意义

Expression of TNFAIP3 in esophageal squamous cell carcinoma and its prognostic significance

目的研究肿瘤坏死因子α诱导蛋白3(tumor necrosis factorα-induced protein 3,TNFAIP3)在食管鳞癌中表达的临床病理意义及其对鳞癌预后的判断价值。方法免疫组织化学法检测100例随访食管鳞癌及80例癌旁组织中TNFAIP3蛋白的表达,并分析了其与食管鳞癌临床病理特征及预后的关系。结果TNFAIP3在食管鳞癌中高表达阳性率为47.0%(47/100),显著高于癌旁组织中的高表达率15.0%(12/80),且与肿瘤的分化程度有关;生存分析显示高表达TNFAIP3的患者预后不良,单因素生存分析显示TNFAIP3的表达、肿瘤的浸润深度、淋巴结转移、临床分期与食管鳞癌预后密切相关,多因素生存分析显示TNFAIP3的表达、肿瘤的浸润深度、淋巴结转移、临床分期为食管鳞癌的独立预后预测因子。结论表达增高的TNFAIP3可能参与了食管鳞癌的发生发展,TNFAIP3的高表达可能成为食管鳞癌的独立预后因子。

Objective To explore the expression of TNFAIP3 in esophageal squamous cell carcinoma(ESCC)and its clinicopathological and prognostic significance.Methods The expression of TNFAIP3 in 100 cases of ESCC and 80 cases of adjacent nonneoplastic esophageal tissues was detected by immunohistochemical method,and then the correlation between TNFAIP3 expression with clinicopathological parameters and prognosis in 100 ESCC patients was analyzed.Results The positive rate of TNFAIP3 high expression in ESCC was 47.0%(47/100),significantly higher than that in nonneoplastic esophageal tissues,which was 15.0%(12/80).The TNFAIP3 protein expression was related to the degree of tumor cell differentiation.Survival analysis shows that patients with high expression of TNFAIP3 have a poor prognosis.Univariate analysis showed that TNFAIP3 expression,depth invasion,lymph node metastasis and AJCC clinical stage were related to poor prognosis of ESCC patients.Multivariate analysis showed TNFAIP3 expression,depth invasion,lymph node metastasis and AJCC clinical stage were independent prognostic factors.Conclusion TNFAIP3 may play an important role in the pathogenesis and development of ESCC,and high expression of TNFAIP3 may be an independent prognostic factor of ESCC.