细胞自噬与肿瘤治疗的研究进展

Recent progress in autophagy and tumor therapy

自噬是一种高度保守的、存在于真核细胞内的自我降解机制,自噬水平异常会破坏细胞内稳态。自噬在肿瘤中既能抑制早期肿瘤发生又可促进肿瘤发展,尤其是其对多种肿瘤治疗有细胞毒性、细胞保护性的双重影响,如何调控自噬用于肿瘤治疗及化疗增敏已成为肿瘤防治领域的研究热点。在本综述中对自噬在肿瘤致病及进展过程中的具体作用展开了总结,重点讨论了自噬对肿瘤治疗的影响及当前靶向自噬改善肿瘤治疗的各种新策略。

Autophagy is a highly conservative self-degradation mechanism that exists in eukaryotic cells.Abnormal levels of autophagy will destroy intracellular homeostasis.Autophagy can not only suppress early tumorigenesis but also promote tumor development,especially it has dual effects of cytotoxicity and cytoprotection on various tumor treatments.How to regulate autophagy for tumor treatment and chemotherapy sensitization has become research hotspots in the field of cancer prevention and treatment.In this review,the specific role of autophagy in the pathogenesis and progression of tumors is summarized,focusing on the impact of autophagy on tumor treatment and the current various new strategies targeted on autophagy to improve tumor treatment.